Bovine Metabolome Database: Showing metabocard for Angiotensin II (BMDB0001035)

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Identification Taxonomy Physical properties Pathways Spectra Concentrations Links References enzymes (4) Show 4 proteins XML

Record Information

Version

1.0

Creation Date

2016-09-30 22:40:11 UTC

Update Date

2020-04-22 15:06:25 UTC

BMDB ID

BMDB0001035

Secondary Accession Numbers

BMDB01035

Metabolite Identification

Common Name

Angiotensin II

Description

Angiotensin II, also known as angiotonin or hypertensin, belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds. Angiotensin II is a very strong basic compound (based on its pKa).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
5-Isoleucine-angiotensin II	ChEBI
5-L-Isoleucineangiotensin II	ChEBI
Angiotensin	ChEBI
Angiotensin II (human)	ChEBI
Angiotensin II (mouse)	ChEBI
Angiotonin	ChEBI
Asp-arg-val-tyr-ile-his-pro-phe	ChEBI
Human angiotensin II	ChEBI
Hypertensin	ChEBI
Isoleucine(5)-angiotensin II	ChEBI
N-(1-(N-(N-(N-(N-(N(2)-L-alpha-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine	ChEBI
Delivert	Kegg
N-(1-(N-(N-(N-(N-(N(2)-L-a-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine	Generator
N-(1-(N-(N-(N-(N-(N(2)-L-Α-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine	Generator
1-8-Angiotensin I	HMDB
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide	HMDB
Ang II	HMDB
Angiotensin 2	HMDB
Ile(5)-angiotensin II	HMDB
II, 5-L-isoleucine angiotensin	HMDB
Isoleucyl(5)-angiotensin II	HMDB
Angiotensin II, 5-L-isoleucine	HMDB
Valyl(5)-angiotensin II	HMDB
ANG-(1-8)octapeptide	HMDB
Isoleucine(5)-angiotensin	HMDB
5 L Isoleucine angiotensin II	HMDB
5-L-Isoleucine angiotensin II	HMDB
Angiotensin-(1-8) octapeptide	HMDB

Chemical Formula

C₅₀H₇₁N₁₃O₁₂

Average Molecular Weight

1046.1786

Monoisotopic Molecular Weight

1045.534514801

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

11128-99-7

SMILES

Not Available

InChI Identifier

InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1

InChI Key

CZGUSIXMZVURDU-JZXHSEFVSA-N

Chemical Taxonomy

Description

belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Oligopeptides

Alternative Parents

Substituents

Alpha-oligopeptide
Tyrosine or derivatives
Phenylalanine or derivatives
Histidine or derivatives
Aspartic acid or derivatives
Isoleucine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
N-acyl-l-alpha-amino acid
Valine or derivatives
Proline or derivatives
Alpha-amino acid amide
3-phenylpropanoic-acid
Alpha-amino acid or derivatives
N-substituted-alpha-amino acid
Amphetamine or derivatives
N-acylpyrrolidine
Pyrrolidine-2-carboxamide
Imidazolyl carboxylic acid derivative
Pyrrolidine carboxylic acid or derivatives
Phenol
1-hydroxy-2-unsubstituted benzenoid
Monocyclic benzene moiety
Dicarboxylic acid or derivatives
Fatty acyl
Fatty amide
Benzenoid
N-acyl-amine
Pyrrolidine
Tertiary carboxylic acid amide
Imidazole
Heteroaromatic compound
Azole
Amino acid or derivatives
Amino acid
Carboxamide group
Guanidine
Secondary carboxylic acid amide
Carboximidamide
Carboxylic acid
Azacycle
Organoheterocyclic compound
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Organooxygen compound
Organopnictogen compound
Carbonyl group
Hydrocarbon derivative
Organic oxygen compound
Primary amine
Organic nitrogen compound
Amine
Organonitrogen compound
Organic oxide
Primary aliphatic amine
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

angiotensin II (CHEBI:2719 )
Angiotensin [KO:K09821] (C02135 )

Ontology

Status

Expected but not Quantified

Origin

Endogenous

Biofunction

Not Available

Application

Not Available

Cellular locations

Not Available

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Angiotensin Metabolism		Not Available

Normal Concentrations

Not Available

Abnormal Concentrations

Not Available

External Links

HMDB ID

HMDB0001035

DrugBank ID

DB11842

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB022383

KNApSAcK ID

Not Available

Chemspider ID

150504

KEGG Compound ID

C02135

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Angiotensin

METLIN ID

Not Available

PubChem Compound

172198

PDB ID

Not Available

ChEBI ID

2719

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Not Available

Enzymes

Enzyme Details

1. Angiotensin-converting enzyme

General function:: Involved in carboxypeptidase activity
Specific function:: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity).
Gene Name:: ACE
Uniprot ID:: P12820
Molecular weight:: 10681.0

Enzyme Details

2. Protein tyrosine phosphatase type IVA 3

General function:: Signal transduction mechanisms
Specific function:: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity).
Gene Name:: PTP4A3
Uniprot ID:: A2VDT1
Molecular weight:: 19511.0

Enzyme Details

3. Type-1 angiotensin II receptor

General function:: Involved in angiotensin type II receptor activity
Specific function:: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Gene Name:: AGTR1
Uniprot ID:: P25104
Molecular weight:: 41088.0

Enzyme Details

4. Angiotensin II receptor-associated protein

General function:: Involved in angiotensin type II receptor activity
Specific function:: Not Available
Gene Name:: AGTRAP
Uniprot ID:: Q17QI4
Molecular weight:: 16552.0

Showing metabocard for Angiotensin II (BMDB0001035)

Structure for BMDB0001035 (Angiotensin II)

Enzymes