| Record Information |
|---|
| Version | 1.0 |
|---|
| Creation Date | 2016-09-30 22:40:28 UTC |
|---|
| Update Date | 2020-05-20 23:10:57 UTC |
|---|
| BMDB ID | BMDB0001056 |
|---|
| Secondary Accession Numbers | |
|---|
| Metabolite Identification |
|---|
| Common Name | Dihydrofolic acid |
|---|
| Description | Dihydrofolic acid, also known as Dihydrofolic acid or dihydrofolic acid, belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Dihydrofolic acid is possibly soluble (in water) and a strong basic compound (based on its pKa). Dihydrofolic acid exists in all eukaryotes, ranging from yeast to humans. Dihydrofolic acid participates in a number of enzymatic reactions, within cattle. In particular, Dihydrofolic acid can be biosynthesized from tetrahydrofolic acid; which is catalyzed by the enzyme dihydrofolic acid reductase. In addition, Dihydrofolic acid can be converted into folic acid; which is mediated by the enzyme dihydrofolic acid reductase. In cattle, dihydrofolic acid is involved in the metabolic pathway called the folate metabolism pathway. |
|---|
| Structure | |
|---|
| Synonyms | | Value | Source |
|---|
| 7,8-Dihydrofolate | ChEBI | | 7,8-Dihydrofolic acid | ChEBI | | 7,8-Dihydropteroylglutamate | ChEBI | | Dihydrofolate | ChEBI | | N-(7,8-Dihydropteroyl)-L-glutamic acid | ChEBI | | 7,8-Dihydropteroylglutamic acid | Generator | | N-(7,8-Dihydropteroyl)-L-glutamate | Generator | | 7,8-Dihydro-L-folic acid | HMDB | | H2PteGlu | HMDB | | H2PteGlu1 | HMDB | | L-N-[p-[[(2-Amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-glutamic acid | HMDB | | N-(4-(((2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid | HMDB | | N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid | HMDB | | N-[4-[[(2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid | HMDB | | N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid | HMDB | | Vitamin b9 | HMDB | | Dihydrofolate, (D)-isomer | HMDB |
|
|---|
| Chemical Formula | C19H21N7O6 |
|---|
| Average Molecular Weight | 443.4133 |
|---|
| Monoisotopic Molecular Weight | 443.155331439 |
|---|
| IUPAC Name | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid |
|---|
| Traditional Name | dihydrofolic acid |
|---|
| CAS Registry Number | 4033-27-6 |
|---|
| SMILES | NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1 |
|---|
| InChI Identifier | InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 |
|---|
| InChI Key | OZRNSSUDZOLUSN-LBPRGKRZSA-N |
|---|
| Chemical Taxonomy |
|---|
| Description | belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. |
|---|
| Kingdom | Organic compounds |
|---|
| Super Class | Organic acids and derivatives |
|---|
| Class | Carboxylic acids and derivatives |
|---|
| Sub Class | Amino acids, peptides, and analogues |
|---|
| Direct Parent | Glutamic acid and derivatives |
|---|
| Alternative Parents | |
|---|
| Substituents | - Glutamic acid or derivatives
- Hippuric acid or derivatives
- Hippuric acid
- N-acyl-alpha-amino acid
- N-acyl-alpha amino acid or derivatives
- Pterin
- Aminobenzamide
- Aminobenzoic acid or derivatives
- Pteridine
- Benzamide
- Benzoic acid or derivatives
- Benzoyl
- Phenylalkylamine
- Aniline or substituted anilines
- Hydroxypyrimidine
- Secondary aliphatic/aromatic amine
- Dicarboxylic acid or derivatives
- Benzenoid
- Pyrimidine
- Monocyclic benzene moiety
- Heteroaromatic compound
- Amino acid
- Secondary carboxylic acid amide
- Ketimine
- Carboxamide group
- Carboxylic acid
- Propargyl-type 1,3-dipolar organic compound
- Secondary amine
- Organoheterocyclic compound
- Organic 1,3-dipolar compound
- Azacycle
- Organic oxygen compound
- Imine
- Hydrocarbon derivative
- Carbonyl group
- Amine
- Organic oxide
- Organonitrogen compound
- Organopnictogen compound
- Organooxygen compound
- Organic nitrogen compound
- Aromatic heteropolycyclic compound
|
|---|
| Molecular Framework | Aromatic heteropolycyclic compounds |
|---|
| External Descriptors | |
|---|
| Ontology |
|---|
| Status | Expected but not Quantified |
|---|
| Origin | |
|---|
| Biofunction | Not Available |
|---|
| Application | Not Available |
|---|
| Cellular locations | |
|---|
| Physical Properties |
|---|
| State | Solid |
|---|
| Experimental Properties | | Property | Value | Reference |
|---|
| Melting Point | Not Available | Not Available | | Boiling Point | Not Available | Not Available | | Water Solubility | Not Available | Not Available | | LogP | Not Available | Not Available |
|
|---|
| Predicted Properties | |
|---|
| Spectra |
|---|
| Spectra | |
|---|
