Record Information |
---|
Version | 1.0 |
---|
Creation Date | 2016-09-30 22:45:21 UTC |
---|
Update Date | 2020-05-21 16:26:56 UTC |
---|
BMDB ID | BMDB0001396 |
---|
Secondary Accession Numbers | |
---|
Metabolite Identification |
---|
Common Name | 5-Methyltetrahydrofolic acid |
---|
Description | 5-Methyltetrahydrofolic acid, also known as 5-methyltetrahydrofolic acid or 5-methyltetrahydrofolic acid, belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit. 5-Methyltetrahydrofolic acid is possibly soluble (in water) and a strong basic compound (based on its pKa). 5-Methyltetrahydrofolic acid exists in all eukaryotes, ranging from yeast to humans. 5-Methyltetrahydrofolic acid participates in a number of enzymatic reactions, within cattle. In particular, Homocysteine and 5-methyltetrahydrofolic acid can be converted into L-methionine and tetrahydrofolic acid through its interaction with the enzyme methionine synthase. In addition, 5-Methyltetrahydrofolic acid can be biosynthesized from 5,10-methylene-THF; which is catalyzed by the enzyme methylenetetrahydrofolate reductase. In cattle, 5-methyltetrahydrofolic acid is involved in a couple of metabolic pathways, which include the betaine metabolism pathway and the folate metabolism pathway. |
---|
Structure | |
---|
Synonyms | Value | Source |
---|
5-Methyltetrahydrofolate | Generator | 5-Methyl tetrahydrofolate | HMDB | 5-Methyl-5,6,7,8-tetrahydrofolate | HMDB | 5-Methyl-tetrahydrofolate | HMDB | 5-Methyltetrahydropteroylglutamate | HMDB | Methyl folate | HMDB | Methyl-tetrahydrofolate | HMDB | N( 5)-Methyltetrahydrofolate | HMDB | N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate | HMDB | N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid | HMDB | N-(5-Methyl-5,6,7,8-tetrahydropteroyl)-L-glutamate | HMDB | N-(5-Methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid | HMDB | N5-Methyl-tetrahydrofolate | HMDB | N5-Methyl-tetrahydrofolic acid | HMDB | N5-Methyltetrahydrofolate | HMDB | N5-Methyltetrahydropteroyl mono-L-glutamate | HMDB | [(6S)-5-Methyl-5,6,7,8-tetrahydropteroyl]glutamate | HMDB | 5-Methyltetrahydrofolate, (DL-glu)-isomer | HMDB | 5-Methyltetrahydrofolate, (L-glu)-(R)-isomer | HMDB | 5-Methyltetrahydrofolate, (L-glu)-(S)-isomer | HMDB | 5-Methyltetrahydrofolate, calcium salt (1:1), (L-glu)-isomer | HMDB | 5-Methyltetrahydrofolate, methyl-(14)C-labeled, (DL-glu)-isomer | HMDB | 5-Methyltetrahydrofolate, methyl-(14)C-labeled, (L-glu)-isomer | HMDB | CH3-FH4 | HMDB | L-Methyl folate | HMDB | N(5)-Methyltetrahydrofolic acid | HMDB | Prefolic a | HMDB | Mefolinate | HMDB | Levomefolic acid | HMDB | L-Methylfolate | HMDB | Deplin | HMDB |
|
---|
Chemical Formula | C20H25N7O6 |
---|
Average Molecular Weight | 459.4558 |
---|
Monoisotopic Molecular Weight | 459.186631567 |
---|
IUPAC Name | Not Available |
---|
Traditional Name | Not Available |
---|
CAS Registry Number | 134-35-0 |
---|
SMILES | Not Available |
---|
InChI Identifier | InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12?,13-/m1/s1 |
---|
InChI Key | ZNOVTXRBGFNYRX-ZGTCLIOFSA-N |
---|
Chemical Taxonomy |
---|
Description | belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit. |
---|
Kingdom | Organic compounds |
---|
Super Class | Organoheterocyclic compounds |
---|
Class | Pteridines and derivatives |
---|
Sub Class | Pterins and derivatives |
---|
Direct Parent | Tetrahydrofolic acids |
---|
Alternative Parents | |
---|
Substituents | - Tetrahydrofolic acid
- Glutamic acid or derivatives
- Hippuric acid or derivatives
- Hippuric acid
- N-acyl-alpha-amino acid
- N-acyl-alpha amino acid or derivatives
- Alpha-amino acid or derivatives
- Aminobenzamide
- Aminobenzoic acid or derivatives
- Benzoic acid or derivatives
- Benzamide
- Benzoyl
- Phenylalkylamine
- Tertiary aliphatic/aromatic amine
- Aniline or substituted anilines
- Dialkylarylamine
- Secondary aliphatic/aromatic amine
- Pyrimidone
- Aminopyrimidine
- Dicarboxylic acid or derivatives
- Benzenoid
- Pyrimidine
- Monocyclic benzene moiety
- Vinylogous amide
- Heteroaromatic compound
- Secondary carboxylic acid amide
- Tertiary amine
- Amino acid or derivatives
- Amino acid
- Carboxamide group
- Secondary amine
- Carboxylic acid
- Carboxylic acid derivative
- Azacycle
- Organic nitrogen compound
- Carbonyl group
- Organonitrogen compound
- Organooxygen compound
- Primary amine
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Amine
- Aromatic heteropolycyclic compound
|
---|
Molecular Framework | Aromatic heteropolycyclic compounds |
---|
External Descriptors | Not Available |
---|
Ontology |
---|
Status | Detected but not Quantified |
---|
Origin | |
---|
Biofunction | Not Available |
---|
Application | Not Available |
---|
Cellular locations | Not Available |
---|
Physical Properties |
---|
State | Solid |
---|
Experimental Properties | Property | Value | Reference |
---|
Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
|
---|
Predicted Properties | Not Available |
---|
Spectra |
---|
Spectra | |
---|