Showing metabocard for Sulfate (BMDB0001448)

General function:

Involved in electron carrier activity

Specific function:

Not Available

Gene Name:

SUOX

Uniprot ID:

Q3MHX0

Molecular weight:

60501.0

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Hydrolyzes cerebroside sulfate.

Gene Name:

ARSA

Uniprot ID:

Q08DD1

Molecular weight:

53807.0

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Not Available

Gene Name:

MPST

Uniprot ID:

Q3MHG3

Molecular weight:

33193.0

General function:

Inorganic ion transport and metabolism

Specific function:

Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron-sulfur complexes and cyanide detoxification. Binds molecular oxygen and sulfur.

Gene Name:

TST

Uniprot ID:

P00586

Molecular weight:

33296.0

General function:

Involved in calcium ion binding

Specific function:

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans. Acts as procoagulant by enhancing the generation of activated factor X/F10 in the presence of tissue factor/TF and activated factor VII/F7. Independent of its enzymatic activity, increases cell adhesion to the extracellular matrix (ECM). Enhances AKT1/PKB phosphorylation, possibly via interaction with a lipid raft-resident receptor. Plays a role in the regulation of osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis (By similarity).

Gene Name:

HPSE

Uniprot ID:

Q9MYY0

Molecular weight:

61077.0

General function:

Involved in calcium ion binding

Specific function:

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).

Gene Name:

COMP

Uniprot ID:

P35445

Molecular weight:

82362.0

General function:

Inorganic ion transport and metabolism

Specific function:

Not Available

Gene Name:

TSTD3

Uniprot ID:

A8R4B3

Molecular weight:

17869.0

General function:

Inorganic ion transport and metabolism

Specific function:

Not Available

Gene Name:

SLC26A6

Uniprot ID:

Q08DQ8

Molecular weight:

83332.0

General function:

Inorganic ion transport and metabolism

Specific function:

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility (By similarity).

Gene Name:

SLC26A8

Uniprot ID:

A6QNW6

Molecular weight:

108744.0

General function:

Involved in cytokine activity

Specific function:

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).

Gene Name:

VEGFA

Uniprot ID:

P15691

Molecular weight:

22310.0

General function:

Involved in anion exchanger activity

Specific function:

Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

Gene Name:

SLC26A11

Uniprot ID:

Q58DD2

Molecular weight:

65350.0

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

May anchor basement membranes to the underlying connective tissue.

Gene Name:

PRELP

Uniprot ID:

Q9GKN8

Molecular weight:

43683.0

General function:

Inorganic ion transport and metabolism

Specific function:

Sulfate transporter. May play a role in endochondral bone formation.

Gene Name:

SLC26A2

Uniprot ID:

Q9BEG8

Molecular weight:

81540.0

General function:

Involved in calcium ion binding

Specific function:

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.

Gene Name:

ADGRE5

Uniprot ID:

Q8SQA4

Molecular weight:

80322.0

General function:

Inorganic ion transport and metabolism

Specific function:

Chloride/bicarbonate exchanger.

Gene Name:

SLC26A3

Uniprot ID:

A4IFH8

Molecular weight:

84344.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

PAPSS2

Uniprot ID:

Q0VC88

Molecular weight:

69672.0

Reactions