Showing metabocard for Beta-D-Glucose 6-phosphate (BMDB0003498)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (3) Show 3 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 23:04:55 UTC
Update Date2020-05-21 16:28:59 UTC
BMDB IDBMDB0003498
Secondary Accession Numbers
  • BMDB03498
Metabolite Identification
Common NameBeta-D-Glucose 6-phosphate
Descriptionbeta-D-Glucose 6-phosphate, also known as b-D-glucose 6-phosphoric acid or 6-O-phosphono-b-D-glucopyranose, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. beta-D-Glucose 6-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). beta-D-Glucose 6-phosphate exists in all living species, ranging from bacteria to humans.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
6-H2PO3glcbetaChEBI
6-O-Phosphono-beta-D-glucopyranoseChEBI
beta-D-Glucose 6-(dihydrogen phosphate)ChEBI
beta-D-Glucose 6-phosphic acidChEBI
BETA-D-GLUCOSE-6-phosphATEChEBI
6-O-Phosphono-b-D-glucopyranoseGenerator
6-O-Phosphono-β-D-glucopyranoseGenerator
b-D-Glucose 6-(dihydrogen phosphate)Generator
b-D-Glucose 6-(dihydrogen phosphoric acid)Generator
beta-D-Glucose 6-(dihydrogen phosphoric acid)Generator
Β-D-glucose 6-(dihydrogen phosphate)Generator
Β-D-glucose 6-(dihydrogen phosphoric acid)Generator
b-D-Glucose 6-phosphateGenerator
b-D-Glucose 6-phosphoric acidGenerator
beta-D-Glucose 6-phosphoric acidGenerator
Β-D-glucose 6-phosphateGenerator
Β-D-glucose 6-phosphoric acidGenerator
b-D-GLUCOSE-6-phosphateGenerator
b-D-GLUCOSE-6-phosphoric acidGenerator
beta-D-GLUCOSE-6-phosphoric acidGenerator
Β-D-glucose-6-phosphateGenerator
Β-D-glucose-6-phosphoric acidGenerator
Chemical FormulaC6H13O9P
Average Molecular Weight260.1358
Monoisotopic Molecular Weight260.029718526
IUPAC Name{[(2R,3S,4S,5R,6R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid
Traditional Nameβ-D-glucose 6-phosphate
CAS Registry NumberNot Available
SMILES
O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O
InChI Identifier
InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6-/m1/s1
InChI KeyNBSCHQHZLSJFNQ-VFUOTHLCSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentHexose phosphates
Alternative Parents
Substituents
  • Hexose phosphate
  • Monosaccharide phosphate
  • Monoalkyl phosphate
  • Organic phosphoric acid derivative
  • Alkyl phosphate
  • Oxane
  • Phosphoric acid ester
  • Hemiacetal
  • Secondary alcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Polyol
  • Hydrocarbon derivative
  • Alcohol
  • Organic oxide
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.643Not Available
Predicted Properties
PropertyValueSource
logP-2.1ALOGPS
logP-3.1ChemAxon
logS-0.92ALOGPS
pKa (Strongest Acidic)1.22ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area156.91 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity46.8 m³·mol⁻¹ChemAxon
Polarizability20.96 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
HMDB IDHMDB0003498
DrugBank IDDB04122
Phenol Explorer Compound IDNot Available
FooDB IDFDB031291
KNApSAcK IDNot Available
Chemspider ID388538
KEGG Compound IDC01172
BioCyc IDGLC-6-P
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound439427
PDB IDNot Available
ChEBI ID17719
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Hexokinase-1
General function:
Involved in ATP binding
Specific function:
Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).
Gene Name:
HK1
Uniprot ID:
P27595
Molecular weight:
103064.0
Reactions
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Beta-D-Glucose + Adenosine triphosphate → Beta-D-Glucose 6-phosphate + ADPdetails
Enzyme Details
2. Glucose-6-phosphate isomerase
General function:
Carbohydrate transport and metabolism
Specific function:
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
Gene Name:
GPI
Uniprot ID:
Q3ZBD7
Molecular weight:
62855.0
Reactions
Beta-D-Glucose 6-phosphate → Fructose 6-phosphatedetails
Beta-D-Glucose 6-phosphate → Glucose 6-phosphatedetails
Enzyme Details
3. Glucose-6-phosphate 1-dehydrogenase
General function:
Not Available
Specific function:
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
Gene Name:
G6PD
Uniprot ID:
F1MMK2
Molecular weight:
62414.0
Reactions
Beta-D-Glucose 6-phosphate + NADP → Gluconolactone + NADPHdetails