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| Identification |
|---|
| BMDB Protein ID
| BMDBP00024 |
| Secondary Accession Numbers
| |
| Name
| Prostacyclin synthase |
| Synonyms
|
Not Available
|
| Gene Name
| PTGIS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). |
| Pathways
|
Not Available
|
| Reactions
|
| Prostaglandin H2 → Prostaglandin I2 |
details
|
| 7a-Hydroxy-cholestene-3-one + NADPH + Oxygen → 7a,12a-Dihydroxy-cholestene-3-one + NADP + Water |
details
|
| Cholesterol + 3 NADPH + 3 Oxygen → 27-Hydroxycholesterol +3 NADP +4 Water |
details
|
| 27-Hydroxycholesterol + NADPH + Oxygen → 7-a,27-dihydroxycholesterol + NADP + Water |
details
|
| 3beta-Hydroxy-5-cholestenoic acid + NADPH + Oxygen → 3 beta,7 alpha-Dihydroxy-5-cholestenoate + NADP + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| PTGIS |
| Gene Sequence
|
>1503 bp
ATGTCCTGGGCCGTGGTCTTCGGCCTCCTGGCCGCGCTGCTGCTGCTGCTGCTGCTGACC
CGCCGCCGCACGCGGCGACCTGGCGAGCCTCCCCTGGACCTGGGCAGTATCCCCTGGCTG
GGTCACGCCTTGGAGTTTGGAAAAGATGCTGCCGGCTTCCTCACTAGGATGAAGGAGAAG
CATGGGGACATCTTTACTGTGCTGGTGGGCGGCAGGCACGTCACGGTCCTCCTGGATCCC
CACTCCTACGACGCGGTGGTGTGGGAGCCCCGCAGCAGGCTGGACTTCCACGCCTACGCC
GTCTTCCTCATGGAGAGGATTTTCGACGTGCAGCTTCCGCATTATAACCCCGGTGATGAA
AAGTCCAAGATGAAACCGACTCTCCTCCACAAAGAGCTGCAGGCGCTCACGGATGCCATG
TATACCAACCTCCGCACTGTCCTGCTGGGTGACACCGTGGAAGCGGGCAGTGGCTGGCAC
GAAATGGGGCTCCTCGAGTTCTCCTACGGCTTCCTGCTCAGAGCCGGCTACCTGACCCAG
TACGGCGTTGAGGCACCGCCACACACCCAGGAGAGCCAGGCCCAGGACCGTGTCCACTCA
GCCGACGTCTTCCACACCTTCCGCCAGCTTGACCTGCTGCTCCCCAAGCTGGCACGTGGC
TCCCTGTCAGCGGGGGATAAGGACCGGGTGGGCAAGGTCAAAGGTCGCCTGTGGAAGCTG
TTGTCCCCAACCAGGCTGGCCAGCCGGGCCCACCGGAGCAGATGGCTGGAGAGTTACCTG
CTGCACCTGGAGGAGATGGGCGTGTCGGAGGAGATGCAGGCTCGCGCCCTGGTGCTGCAG
CTCTGGGCCACACAGGGGAACATGGGTCCTGCTGCCTTCTGGCTCCTGCTCTTTCTCCTC
AAGAACCCCGAGGCCCTGGCCGCTGTCCGTGGAGAGCTAGAGACTGTCCTTTTGGGAGCA
GAGCAGCCCATATCACAGATGACCACCCTCCCACAGAAAGTTTTGGACAGCATGCCTGTG
CTGGACAGCGTGCTGAGTGAGAGCCTCAGGCTCACCGCCGCGCCCTTCATCACCCGCGAG
GTCGTGGCCGACCTGGCCTTGCCCATGGCGGATGGGCGGGAATTCAGCCTGCGACGTGGG
GACCGCCTCCTCCTCTTTCCCTTCCTGAGTCCCCAGAAGGACCCGGAGATCTACACAGAC
CCGGAGGTATTTAAATACAACCGATTCCTGAACCCTGATGGATCAGAGAAGAAAGACTTT
TACAAAGATGGGAAGCGACTGAAGAACTACAGCTTGCCGTGGGGAGCAGGGCATAACCAG
TGCCTGGGGAAGGGTTACGCCGTCAACAGCATCAAACAATTCGTGTTCCTTGTGCTGACG
CAGTTTGACCTGGAGCTGATCACCCCGGACGTGGACATCCCCGAGTTTGACCTCAGCAGG
TATGGCTTTGGGCTGATGCAGCCGGAACACGATGTGCCTGTCCGTTACCGCATCCGGCCG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 500 |
| Molecular Weight
| 56629.0 |
| Theoretical pI
| 7.29 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Prostacyclin synthase
MSWAVVFGLLAALLLLLLLTRRRTRRPGEPPLDLGSIPWLGHALEFGKDAAGFLTRMKEK
HGDIFTVLVGGRHVTVLLDPHSYDAVVWEPRSRLDFHAYAVFLMERIFDVQLPHYNPGDE
KSKMKPTLLHKELQALTDAMYTNLRTVLLGDTVEAGSGWHEMGLLEFSYGFLLRAGYLTQ
YGVEAPPHTQESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSAGDKDRVGKVKGRLWKL
LSPTRLASRAHRSRWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELETVLLGAEQPISQMTTLPQKVLDSMPVLDSVLSESLRLTAAPFITRE
VVADLALPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTDPEVFKYNRFLNPDGSEKKDF
YKDGKRLKNYSLPWGAGHNQCLGKGYAVNSIKQFVFLVLTQFDLELITPDVDIPEFDLSR
YGFGLMQPEHDVPVRYRIRP
|
| External Links |
|---|
| GenBank ID Protein
| BAA06383.1 |
| UniProtKB/Swiss-Prot ID
| Q29626 |
| UniProtKB/Swiss-Prot Entry Name
| PTGIS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D30718 |
| GeneCard ID
| PTGIS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
