| Identification |
|---|
| BMDB Protein ID
| BMDBP00359 |
| Secondary Accession Numbers
| None |
| Name
| Hydroxymethylglutaryl-CoA synthase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| HMGCS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. |
| Pathways
|
- (R)-mevalonate biosynthesis
- (R)-mevalonate from acetyl-CoA: step 2/3
- Butyrate Metabolism
- Ketone Body Metabolism
- Metabolic intermediate biosynthesis
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| Acetyl-CoA + Acetoacetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| HMGCS2 |
| Gene Sequence
|
>1527 bp
ATGCAGCGGCTGTTGACTCCAGTGAGGCAGGTGTTGCAAGTGAAGAGAGTGATGCAAGAA
GCTTCCCTCCTGCCTGCCCGCCTTCTCCCAGCAGCCCACCCCAGTTTTTCTACAGTTCCG
GCTGTCCCCTTGGCCAAAACAGATACTTGGCCAAAGGATGTGGGTATTCTTGCCATGGAG
GTCTACTTTCCAGCCCAATATGTGGACCAAACAGAGCTGGAGAAGTTTAACAAAGTGGAG
GCAGGGAGGTACACCGTGGGCTTGGGCCAGACCCAGATGGGCTTCTGCTCAGTCCAGGAG
GATGTCAACTCCCTGTGCCTGACGGTGGTGCAACAGCTGATGGAGCGCACGCAGCTCCCC
TGGGACTCTGTGGGCCGCCTGGAAGTGGGCACTGAGACCATCATCGATAAGTCCAAGGCT
GTCAAAACAGTGCTTATGGAGCTCTTCCAGGATTCAGGCAACACTGACATTGAGGGCATA
GATACCACCAATGCCTGCTACGGTGGCACTGCCTCCCTCTTCAATGCTGCCAACTGGATG
GAATCCAGCTCCTGGGATGGTCGCTATGCACTGGTGGTCTGTGGGGACATCGCAGTCTAC
CCCAGTGGTAACGCTCGCCCCACAGGCGGGGCTGGAGCTGTGGCAATGCTGGTTGGGCCT
GAGGCCCCTCTGGTCCTCGAGAGAGGGCTTAGAGGAACCCACATGGAGAATGTGTACGAC
TTCTACAAACCAGATGTGACTTCAGAGTACCCACTGGTGGATGGGAAGCTCTCCATCCAG
TGCTACTTACGGGCCCTGGACAAATGCTATGCATTCTACCGTCAAAAGATCGAGAAACAG
TGGAAGCAAGCTGGCATCGATCGGCCTTTCACTCTCGATGATGTGCAGTATATGATTTTT
CACACGCCTTTCTGCAAGTTAGTCCAGAAATCCCTGGCCCGCCTGATGTTCAATGACTTC
CTGTTGGCCAGTGGTGACACACAGACTGGCATCTACAAGGGCTTGGAGGCCTTCAGGGGA
CTAAAGCTGGAAGACACCTACACCAATAAGGATGTAGATAAAGCATTTCTAAAAGCCTCT
CTGAACATGTTCAATAAGAAAACCAAGAACTCCCTCTACCTCTCCACGTACAACGGGAAT
ATGTACACCTCATCCCTATATGGATGCCTGGCCTCACTTCTGGCCCATCACTCTGCCCAA
GACTTGGCTGGCTCCAGGATCGGTGCCTTCTCTTATGGCTCTGGTTTGGCAGCAAGTTTC
TTTTCTTTCCGGGTGTCCCAGGATGCTTCTCCAGGCTCCCCACTGGAGAAGCTGGTATCC
AGTACATCAGACCTGCAGAAACGTCTTGCCTCCCGGAAGCGTGTGTCTCCTGAGGAGTTC
ACAGAAATAATGAACCAAAGAGAACAATACTACCACAAGATGAATTTCTCACCACCTGGT
GATAAGAACAGCCTTTTCCCAGGCACTTGGTACCTGGAGCGAGTGGATGAGCTGTATCGC
AGGAAGTACGCCCGGCGTCCCGTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 508 |
| Molecular Weight
| 56895.0 |
| Theoretical pI
| 8.16 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 34-54
- 84-105
- 117-134
- 140-160
- 172-191
- 245-266
- 272-294
- 362-386
- 406-432
- 453-472
- 484-502
- 586-604
|
| Protein Sequence
|
>Hydroxymethylglutaryl-CoA synthase, mitochondrial
MQRLLTPVRQVLQVKRVMQEASLLPARLLPAAHPSFSTVPAVPLAKTDTWPKDVGILAME
VYFPAQYVDQTELEKFNKVEAGRYTVGLGQTQMGFCSVQEDVNSLCLTVVQQLMERTQLP
WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM
ESSSWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLVGPEAPLVLERGLRGTHMENVYD
FYKPDVTSEYPLVDGKLSIQCYLRALDKCYAFYRQKIEKQWKQAGIDRPFTLDDVQYMIF
HTPFCKLVQKSLARLMFNDFLLASGDTQTGIYKGLEAFRGLKLEDTYTNKDVDKAFLKAS
LNMFNKKTKNSLYLSTYNGNMYTSSLYGCLASLLAHHSAQDLAGSRIGAFSYGSGLAASF
FSFRVSQDASPGSPLEKLVSSTSDLQKRLASRKRVSPEEFTEIMNQREQYYHKMNFSPPG
DKNSLFPGTWYLERVDELYRRKYARRPV
|
| External Links |
|---|
| GenBank ID Protein
| AAI12667.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIE6 |
| UniProtKB/Swiss-Prot Entry Name
| HMCS2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112666 |
| GeneCard ID
| HMGCS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
