Showing metabocard for Acetoacetic acid (BMDB0000060)

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.

Gene Name:

FASN

Uniprot ID:

Q71SP7

Molecular weight:

274554.0

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Not Available

Gene Name:

FAH

Uniprot ID:

A5PKH3

Molecular weight:

46156.0

Reactions

General function:

Energy production and conversion

Specific function:

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).

Gene Name:

ADHFE1

Uniprot ID:

A6QP15

Molecular weight:

50343.0

General function:

Lipid transport and metabolism

Specific function:

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).

Gene Name:

BDH2

Uniprot ID:

Q3T046

Molecular weight:

26662.0

General function:

Lipid transport and metabolism

Specific function:

Not Available

Gene Name:

BDH1

Uniprot ID:

Q02337

Molecular weight:

38391.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

Gene Name:

HMGCL

Uniprot ID:

Q29448

Molecular weight:

34168.0

Reactions

General function:

Not Available

Specific function:

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

Gene Name:

OXCT1

Uniprot ID:

Q24JZ7

Molecular weight:

56453.0

Reactions