Showing metabocard for L-Phenylalanine (BMDB0000159)

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.

Gene Name:

PAH

Uniprot ID:

Q2KIH7

Molecular weight:

51727.0

General function:

Amino acid transport and metabolism

Specific function:

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity).

Gene Name:

GOT1

Uniprot ID:

P33097

Molecular weight:

46399.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine (By similarity).

Gene Name:

TAT

Uniprot ID:

Q58CZ9

Molecular weight:

49691.0

Reactions

General function:

Involved in protein binding

Specific function:

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity).

Gene Name:

GCHFR

Uniprot ID:

Q32L41

Molecular weight:

9557.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC7A5

Uniprot ID:

Q9TU26

Molecular weight:

55110.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

IL4I1

Uniprot ID:

F1N191

Molecular weight:

64479.0

Reactions