Showing metabocard for Urea (BMDB0000294)

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ARG1

Uniprot ID:

Q2KJ64

Molecular weight:

35009.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.

Gene Name:

ARG2

Uniprot ID:

Q58DL1

Molecular weight:

38616.0

General function:

Involved in allantoicase activity

Specific function:

The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

Gene Name:

ALLC

Uniprot ID:

Q2KIG4

Molecular weight:

46084.0

General function:

Involved in urea transmembrane transporter activity

Specific function:

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.

Gene Name:

SLC14A1

Uniprot ID:

Q5QF96

Molecular weight:

41473.0