Showing metabocard for Uridine (BMDB0000296)

General function:

Involved in 5'-nucleotidase activity

Specific function:

May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.

Gene Name:

NT5C2

Uniprot ID:

O46411

Molecular weight:

64841.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Not Available

Gene Name:

PUSL1

Uniprot ID:

A6QP68

Molecular weight:

34022.0

General function:

Involved in cytidine deaminase activity

Specific function:

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

Gene Name:

AICDA

Uniprot ID:

Q2PT36

Molecular weight:

24052.0

General function:

Involved in pseudouridine synthase activity

Specific function:

Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types.

Gene Name:

PUS7

Uniprot ID:

Q08DI8

Molecular weight:

74594.0

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.

Gene Name:

PUS3

Uniprot ID:

Q3SX07

Molecular weight:

55665.0

General function:

Nucleotide transport and metabolism

Specific function:

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity).

Gene Name:

UCK1

Uniprot ID:

Q0P5A4

Molecular weight:

31195.0

Reactions

General function:

Not Available

Specific function:

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Gene Name:

UPP2

Uniprot ID:

Q0VCM7

Molecular weight:

35805.0

Reactions