Showing metabocard for Hydrogen carbonate (BMDB0000595)

General function:

Defense mechanisms

Specific function:

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).

Gene Name:

CFTR

Uniprot ID:

P35071

Molecular weight:

167758.0

General function:

Lipid transport and metabolism

Specific function:

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.

Gene Name:

ACACA

Uniprot ID:

Q9TTS3

Molecular weight:

265303.0

Reactions

General function:

Involved in ATP binding

Specific function:

This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).

Gene Name:

PCCB

Uniprot ID:

Q2TBR0

Molecular weight:

58311.0

Reactions

General function:

Energy production and conversion

Specific function:

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

Gene Name:

ALDH6A1

Uniprot ID:

Q07536

Molecular weight:

58063.0

Reactions

General function:

Involved in ATP binding

Specific function:

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity).

Gene Name:

PC

Uniprot ID:

Q29RK2

Molecular weight:

129698.0

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Not Available

Gene Name:

SLC26A6

Uniprot ID:

Q08DQ8

Molecular weight:

83332.0

General function:

Involved in ferric iron binding

Specific function:

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Gene Name:

TF

Uniprot ID:

Q29443

Molecular weight:

77753.0

General function:

Involved in sugar binding

Specific function:

Might act as an inhibitor of spontaneous calcium carbonate precipitation.

Gene Name:

PTP

Uniprot ID:

P23132

Molecular weight:

19334.0

General function:

Involved in inorganic anion exchanger activity

Specific function:

Not Available

Gene Name:

SLC4A4

Uniprot ID:

B2NIZ2

Molecular weight:

121375.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

CAD

Uniprot ID:

F1MVC0

Molecular weight:

243038.0

Reactions