Showing metabocard for D-Glyceraldehyde 3-phosphate (BMDB0001112)

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Gene Name:

DERA

Uniprot ID:

Q3T0V9

Molecular weight:

35246.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).

Gene Name:

GAPDH

Uniprot ID:

P10096

Molecular weight:

35868.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).

Gene Name:

GAPDHS

Uniprot ID:

Q2KJE5

Molecular weight:

43288.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

ALDOA

Uniprot ID:

A6QLL8

Molecular weight:

39436.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

ALDOC

Uniprot ID:

Q3ZBY4

Molecular weight:

39382.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

ALDOB

Uniprot ID:

A5PK73

Molecular weight:

39527.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

ALDOB

Uniprot ID:

Q3T0S5

Molecular weight:

39543.0

General function:

Energy production and conversion

Specific function:

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Gene Name:

TKT

Uniprot ID:

Q6B855

Molecular weight:

67906.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

GAPDL17

Uniprot ID:

Q9XSN4

Molecular weight:

11514.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q862K5

Molecular weight:

15626.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

GAPDH

Uniprot ID:

Q0QES8

Molecular weight:

24259.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

gapdh

Uniprot ID:

Q4H0Z3

Molecular weight:

10913.0

General function:

Carbohydrate transport and metabolism

Specific function:

Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

Gene Name:

TPI1

Uniprot ID:

Q5E956

Molecular weight:

26690.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

GAPDH

Uniprot ID:

Q712W6

Molecular weight:

28755.0