Showing metabocard for Glyceric acid 1,3-biphosphate (BMDB0001270)

General function:

Carbohydrate transport and metabolism

Specific function:

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).

Gene Name:

GAPDH

Uniprot ID:

P10096

Molecular weight:

35868.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).

Gene Name:

GAPDHS

Uniprot ID:

Q2KJE5

Molecular weight:

43288.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

GAPDL17

Uniprot ID:

Q9XSN4

Molecular weight:

11514.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q862K5

Molecular weight:

15626.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

GAPDH

Uniprot ID:

Q0QES8

Molecular weight:

24259.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

gapdh

Uniprot ID:

Q4H0Z3

Molecular weight:

10913.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

GAPDH

Uniprot ID:

Q712W6

Molecular weight:

28755.0

General function:

Carbohydrate transport and metabolism

Specific function:

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

Gene Name:

PGAM2

Uniprot ID:

Q32KV0

Molecular weight:

28685.0

General function:

Carbohydrate transport and metabolism

Specific function:

Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.

Gene Name:

BPGM

Uniprot ID:

Q3T014

Molecular weight:

30061.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

Gene Name:

PGAM1

Uniprot ID:

Q3SZ62

Molecular weight:

28852.0

General function:

Carbohydrate transport and metabolism

Specific function:

Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.

Gene Name:

PGK1

Uniprot ID:

Q3T0P6

Molecular weight:

44538.0

Reactions

General function:

Involved in ATP binding

Specific function:

Plays a role in the physiological regulation of coenzyme A (CoA) levels.

Gene Name:

PANK3

Uniprot ID:

Q08DA5

Molecular weight:

41117.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

PGM2L1

Uniprot ID:

A5PKH8

Molecular weight:

70419.0

Reactions