Showing metabocard for Citicoline (BMDB0001413)

General function:

Involved in ADP-ribose diphosphatase activity

Specific function:

Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

Gene Name:

ADPRM

Uniprot ID:

A7YY53

Molecular weight:

39235.0

General function:

Lipid transport and metabolism

Specific function:

Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity).

Gene Name:

CHPT1

Uniprot ID:

Q1LZE6

Molecular weight:

45249.0

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine (By similarity).

Gene Name:

PCYT2

Uniprot ID:

Q5EA75

Molecular weight:

44158.0

Reactions

General function:

Energy production and conversion

Specific function:

Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).

Gene Name:

GDE1

Uniprot ID:

Q3T0T0

Molecular weight:

37653.0

Reactions

General function:

Involved in hydrolase activity

Specific function:

Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity).

Gene Name:

LYPLA1

Uniprot ID:

Q3MHR0

Molecular weight:

24596.0

Reactions