Showing metabocard for 5,6-Dihydroxyindole (BMDB0004058)

General function:

Involved in cytokine activity

Specific function:

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).

Gene Name:

MIF

Uniprot ID:

P80177

Molecular weight:

12343.0

General function:

Involved in D-dopachrome decarboxylase activity

Specific function:

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

Gene Name:

DDT

Uniprot ID:

A5PK65

Molecular weight:

12877.0

General function:

Involved in dopachrome isomerase activity

Specific function:

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.

Gene Name:

DCT

Uniprot ID:

Q95119

Molecular weight:

58787.0

General function:

Involved in copper ion binding

Specific function:

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.

Gene Name:

TYR

Uniprot ID:

Q8MIU0

Molecular weight:

60304.0

Reactions