Showing metabocard for Adenosine (BMDB0000050)

General function:

Nucleotide transport and metabolism

Specific function:

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Gene Name:

PNP

Uniprot ID:

P55859

Molecular weight:

32037.0

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Not Available

Gene Name:

AHCYL1

Uniprot ID:

A5PKK6

Molecular weight:

68585.0

General function:

Coenzyme transport and metabolism

Specific function:

May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity).

Gene Name:

AHCYL2

Uniprot ID:

A6QLP2

Molecular weight:

66774.0

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity).

Gene Name:

ADA

Uniprot ID:

P56658

Molecular weight:

40919.0

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

Gene Name:

AHCY

Uniprot ID:

Q3MHL4

Molecular weight:

47638.0

Reactions

General function:

Not Available

Specific function:

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.

Gene Name:

ADORA3

Uniprot ID:

Q0VC81

Molecular weight:

35911.0

General function:

Involved in adenosine receptor activity, G-protein coupled

Specific function:

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).

Gene Name:

ADORA2B

Uniprot ID:

Q1LZD0

Molecular weight:

36385.0

General function:

Involved in hydrolase activity

Specific function:

Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides.

Gene Name:

NUDT21

Uniprot ID:

Q3ZCA2

Molecular weight:

26227.0

General function:

Involved in adenosine receptor activity, G-protein coupled

Specific function:

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Gene Name:

ADORA1

Uniprot ID:

P28190

Molecular weight:

36593.0