Showing metabocard for Formic acid (BMDB0000142)

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

Gene Name:

CYP19A1

Uniprot ID:

P46194

Molecular weight:

58090.0

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

Gene Name:

CYP51A1

Uniprot ID:

Q4PJW3

Molecular weight:

56596.0

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde.

Gene Name:

ESD

Uniprot ID:

Q08E20

Molecular weight:

31548.0

General function:

Nucleotide transport and metabolism

Specific function:

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.

Gene Name:

MTHFD1L

Uniprot ID:

Q0VCR7

Molecular weight:

105227.0

General function:

Involved in protein binding

Specific function:

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity).

Gene Name:

GCHFR

Uniprot ID:

Q32L41

Molecular weight:

9557.0

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Not Available

Gene Name:

SLC26A6

Uniprot ID:

Q08DQ8

Molecular weight:

83332.0

General function:

Not Available

Specific function:

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.

Gene Name:

AFMID

Uniprot ID:

E1BLL5

Molecular weight:

35460.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

GCH1

Uniprot ID:

F1MZ14

Molecular weight:

27726.0

Reactions