Showing metabocard for L-Alanine (BMDB0000161)

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.

Gene Name:

SCLY

Uniprot ID:

A2VDS1

Molecular weight:

47204.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).

Gene Name:

AGXT2

Uniprot ID:

Q17QF0

Molecular weight:

57226.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).

Gene Name:

GPT

Uniprot ID:

A4IFH5

Molecular weight:

55275.0

General function:

Involved in DNA binding

Specific function:

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

Gene Name:

PPP1R8

Uniprot ID:

Q28147

Molecular weight:

38521.0

General function:

Involved in acyltransferase activity

Specific function:

Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.

Gene Name:

GGCT

Uniprot ID:

Q32LE4

Molecular weight:

21177.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

AGXT

Uniprot ID:

A7MBF1

Molecular weight:

45292.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Gene Name:

AARS1

Uniprot ID:

A6QLT9

Molecular weight:

106655.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity).

Gene Name:

SLC38A5

Uniprot ID:

Q5E9S9

Molecular weight:

51958.0

General function:

Not Available

Specific function:

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Gene Name:

AARS2

Uniprot ID:

F1MKA6

Molecular weight:

106520.0

Reactions

General function:

Not Available

Specific function:

Cleaves glutathione conjugates.

Gene Name:

GGT6

Uniprot ID:

A7YWM1

Molecular weight:

49626.0

Reactions

General function:

Not Available

Specific function:

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Gene Name:

KYNU

Uniprot ID:

F1MCH2

Molecular weight:

52186.0

Reactions