Showing metabocard for L-Fucose (BMDB0000174)

General function:

Involved in O-fucosylpeptide 3-beta-N-acetylglucosaminy

Specific function:

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning.

Gene Name:

LFNG

Uniprot ID:

Q2KJ92

Molecular weight:

41847.0

General function:

Carbohydrate transport and metabolism

Specific function:

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Gene Name:

FUCA1

Uniprot ID:

Q2KIM0

Molecular weight:

54089.0

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity).

Gene Name:

COLEC12

Uniprot ID:

A6QP79

Molecular weight:

81751.0

General function:

Carbohydrate transport and metabolism

Specific function:

Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense.

Gene Name:

CL43

Uniprot ID:

P42916

Molecular weight:

33616.0

General function:

Involved in binding

Specific function:

Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.

Gene Name:

COLEC11

Uniprot ID:

Q17QH6

Molecular weight:

28333.0

General function:

Carbohydrate transport and metabolism

Specific function:

Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N-acetylglucosamine, mannose, and fucose residues.

Gene Name:

CGN1

Uniprot ID:

P23805

Molecular weight:

37995.0

General function:

Cell cycle control, cell division, chromosome partitioning

Specific function:

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Gene Name:

bovine proacrosine

Uniprot ID:

P79343

Molecular weight:

41722.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

FCSK

Uniprot ID:

A6QP44

Molecular weight:

116951.0

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