Showing metabocard for Myoinositol (BMDB0000211)

General function:

Involved in inositol oxygenase activity

Specific function:

Not Available

Gene Name:

MIOX

Uniprot ID:

A7MBE4

Molecular weight:

32973.0

Reactions

General function:

Replication, recombination and repair

Specific function:

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Gene Name:

NUDT11

Uniprot ID:

Q58CW0

Molecular weight:

18519.0

General function:

Carbohydrate transport and metabolism

Specific function:

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate.

Gene Name:

IMPA1

Uniprot ID:

P20456

Molecular weight:

30056.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.

Gene Name:

IMPAD1

Uniprot ID:

Q2KJ53

Molecular weight:

38924.0

General function:

Energy production and conversion

Specific function:

Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).

Gene Name:

GDE1

Uniprot ID:

Q3T0T0

Molecular weight:

37653.0

General function:

Replication, recombination and repair

Specific function:

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity).

Gene Name:

NUDT3

Uniprot ID:

A2VE79

Molecular weight:

19362.0

General function:

Involved in sodium ion binding

Specific function:

Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

Gene Name:

SLC5A11

Uniprot ID:

Q3ZC26

Molecular weight:

73957.0

General function:

Involved in transporter activity

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

O19135

Molecular weight:

79621.0