Showing metabocard for Phosphoserine (BMDB0000272)

General function:

Involved in protein domain specific binding

Specific function:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).

Gene Name:

YWHAZ

Uniprot ID:

P63103

Molecular weight:

27745.0

General function:

Involved in protein domain specific binding

Specific function:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).

Gene Name:

YWHAH

Uniprot ID:

P68509

Molecular weight:

28212.0

General function:

Involved in insulin-like growth factor receptor binding

Specific function:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Gene Name:

YWHAG

Uniprot ID:

P68252

Molecular weight:

28253.0

General function:

Involved in protein domain specific binding

Specific function:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.

Gene Name:

YWHAB

Uniprot ID:

P68250

Molecular weight:

28081.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity).

Gene Name:

PSPH

Uniprot ID:

Q2KHU0

Molecular weight:

24850.0

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Not Available

Gene Name:

PSAT1

Uniprot ID:

A6QR28

Molecular weight:

40529.0

Reactions

General function:

Involved in protein domain specific binding

Specific function:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).

Gene Name:

YWHAQ

Uniprot ID:

Q3SZI4

Molecular weight:

27764.0

General function:

Not Available

Specific function:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:7931346). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:7931346). Binding generally results in the modulation of the activity of the binding partner (PubMed:7931346). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (By similarity).

Gene Name:

YWHAE

Uniprot ID:

P62261

Molecular weight:

29174.0

General function:

Involved in protein domain specific binding

Specific function:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity).

Gene Name:

SFN

Uniprot ID:

Q0VC36

Molecular weight:

27849.0