Showing metabocard for Mannose 6-phosphate (BMDB0001078)

General function:

Involved in ATP binding

Specific function:

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).

Gene Name:

HK1

Uniprot ID:

P27595

Molecular weight:

103064.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Gene Name:

MPI

Uniprot ID:

Q3SZI0

Molecular weight:

46369.0

Reactions

General function:

Involved in phosphomannomutase activity

Specific function:

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Gene Name:

PMM2

Uniprot ID:

Q3SZJ9

Molecular weight:

27997.0

Reactions

General function:

Involved in mannose binding

Specific function:

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Gene Name:

M6PR

Uniprot ID:

P11456

Molecular weight:

31201.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

PLIN3

Uniprot ID:

Q3SX32

Molecular weight:

47603.0

General function:

Involved in receptor activity

Specific function:

Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

Gene Name:

IGF2R

Uniprot ID:

P08169

Molecular weight:

274529.0