Showing metabocard for Glucose 6-phosphate (BMDB0001401)

General function:

Involved in glucose-6-phosphatase activity

Specific function:

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).

Gene Name:

G6PC

Uniprot ID:

Q29RU6

Molecular weight:

40827.0

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General function:

Involved in glucose-6-phosphatase activity

Specific function:

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity).

Gene Name:

G6PC3

Uniprot ID:

Q148G2

Molecular weight:

38742.0

General function:

Carbohydrate transport and metabolism

Specific function:

This enzyme participates in both the breakdown and synthesis of glucose.

Gene Name:

PGM1

Uniprot ID:

Q08DP0

Molecular weight:

61589.0

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General function:

Involved in ADP-specific glucokinase activity

Specific function:

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Gene Name:

ADPGK

Uniprot ID:

A2VE47

Molecular weight:

54086.0

General function:

Involved in ATP binding

Specific function:

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).

Gene Name:

HK1

Uniprot ID:

P27595

Molecular weight:

103064.0

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General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

H6PD

Uniprot ID:

Q0P587

Molecular weight:

31064.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q5EM56

Molecular weight:

24814.0

General function:

Lipid transport and metabolism

Specific function:

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).

Gene Name:

ISYNA1

Uniprot ID:

Q2NL29

Molecular weight:

60761.0

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General function:

Carbohydrate transport and metabolism

Specific function:

Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

Gene Name:

PYGB

Uniprot ID:

Q3B7M9

Molecular weight:

96340.0

General function:

Carbohydrate transport and metabolism

Specific function:

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity).

Gene Name:

PYGL

Uniprot ID:

Q0VCM4

Molecular weight:

97456.0

General function:

Carbohydrate transport and metabolism

Specific function:

In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).

Gene Name:

GPI

Uniprot ID:

Q3ZBD7

Molecular weight:

62855.0

Reactions