Bovine Metabolome Database: Showing metabocard for O-Phosphothreonine (BMDB0011185)

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Identification Taxonomy Physical properties Pathways Spectra Concentrations Links References enzymes (7) Show 7 proteins XML

Record Information

Version

1.0

Creation Date

2016-10-03 18:14:16 UTC

Update Date

2020-04-22 15:43:09 UTC

BMDB ID

BMDB0011185

Secondary Accession Numbers

BMDB11185

Metabolite Identification

Common Name

O-Phosphothreonine

Description

O-Phosphothreonine, also known as L-threonine phosphate or phosphate, threonine, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. O-Phosphothreonine is a very strong basic compound (based on its pKa). O-Phosphothreonine exists in all living organisms, ranging from bacteria to humans.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
L-Threonine phosphate	Kegg
O-Phospho-L-threonine	Kegg
L-Threonine phosphoric acid	Generator
(2S,3R)-2-Amino-3-hydroxybutanoic acid 3-phosphate	HMDB
L-Threonine O-3-phosphate	HMDB
O3-Phosphothreonine	HMDB
Phosphothreonine	HMDB
Threonine phosphate ester	HMDB
Threoninium dihydrogen phosphate	HMDB
(2S,3R)-2-Amino-3-hydroxybutanoate 3-phosphate	HMDB
(2S,3R)-2-Amino-3-hydroxybutanoic acid 3-phosphoric acid	HMDB
L-Threonine O-3-phosphoric acid	HMDB
Threonine phosphoric acid ester	HMDB
Threoninium dihydrogen phosphoric acid	HMDB
Phosphate, threonine	HMDB
Threonine phosphate	HMDB

Chemical Formula

C₄H₁₀NO₆P

Average Molecular Weight

199.0991

Monoisotopic Molecular Weight

199.024573569

IUPAC Name

(2S,3R)-2-amino-3-(phosphonooxy)butanoic acid

Traditional Name

phosphothreonine

CAS Registry Number

1114-81-4

SMILES

C[C@@H](OP(O)(O)=O)[C@H](N)C(O)=O

InChI Identifier

InChI=1S/C4H10NO6P/c1-2(3(5)4(6)7)11-12(8,9)10/h2-3H,5H2,1H3,(H,6,7)(H2,8,9,10)/t2-,3+/m1/s1

InChI Key

USRGIUJOYOXOQJ-GBXIJSLDSA-N

Chemical Taxonomy

Description

belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Phosphoethanolamine
Monoalkyl phosphate
Organic phosphoric acid derivative
Phosphoric acid ester
Fatty acid
Alkyl phosphate
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Amine
Primary amine
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Organic oxygen compound
Primary aliphatic amine
Organic nitrogen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

non-proteinogenic L-alpha-amino acid (CHEBI:37525 )
L-threonine derivative (CHEBI:37525 )
O-phosphoamino acid (CHEBI:37525 )

Ontology

Status

Expected but not Quantified

Origin

Endogenous

Biofunction

Not Available

Application

Not Available

Cellular locations

Not Available

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-1.9	ALOGPS
logP	-2.7	ChemAxon
logS	-0.93	ALOGPS
pKa (Strongest Acidic)	1.21	ChemAxon
pKa (Strongest Basic)	9.47	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	130.08 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	37.33 m³·mol⁻¹	ChemAxon
Polarizability	15.43 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0002-9200000000-7e906e7246b3ef636b98	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive	splash10-0002-9110000000-0b27bac67efac2895d49	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-6900000000-6cd4ab972cda9b9e8854	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0pb9-9300000000-7755990490f9b0d090c2	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0a4i-9100000000-f7e90830423c5451204b	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-6900000000-ad7260fbe15d44575ebf	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9500000000-c0ec684a681c34652a92	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9000000000-d20cfbbcad9f78ca2901	View in MoNA

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Pathways

Not Available

Name	SMPDB/Pathwhiz	KEGG

Normal Concentrations

Not Available

Abnormal Concentrations

Not Available

External Links

HMDB ID

HMDB0011185

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB027954

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

C12147

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Threonine

METLIN ID

Not Available

PubChem Compound

3246323

PDB ID

TPO

ChEBI ID

37525

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Not Available

Enzymes

Enzyme Details

1. 14-3-3 protein zeta/delta

General function:: Involved in protein domain specific binding
Specific function:: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Gene Name:: YWHAZ
Uniprot ID:: P63103
Molecular weight:: 27745.0

Enzyme Details

2. 14-3-3 protein eta

General function:: Involved in protein domain specific binding
Specific function:: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).
Gene Name:: YWHAH
Uniprot ID:: P68509
Molecular weight:: 28212.0

Enzyme Details

3. 14-3-3 protein gamma

General function:: Involved in insulin-like growth factor receptor binding
Specific function:: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Gene Name:: YWHAG
Uniprot ID:: P68252
Molecular weight:: 28253.0

Enzyme Details

4. 14-3-3 protein beta/alpha

General function:: Involved in protein domain specific binding
Specific function:: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Gene Name:: YWHAB
Uniprot ID:: P68250
Molecular weight:: 28081.0

Enzyme Details

5. 14-3-3 protein theta

General function:: Involved in protein domain specific binding
Specific function:: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).
Gene Name:: YWHAQ
Uniprot ID:: Q3SZI4
Molecular weight:: 27764.0

Enzyme Details

6. 14-3-3 protein epsilon

General function:: Not Available
Specific function:: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:7931346). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:7931346). Binding generally results in the modulation of the activity of the binding partner (PubMed:7931346). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (By similarity).
Gene Name:: YWHAE
Uniprot ID:: P62261
Molecular weight:: 29174.0

Enzyme Details

7. 14-3-3 protein sigma

General function:: Involved in protein domain specific binding
Specific function:: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity).
Gene Name:: SFN
Uniprot ID:: Q0VC36
Molecular weight:: 27849.0

Showing metabocard for O-Phosphothreonine (BMDB0011185)

Structure for BMDB0011185 (O-Phosphothreonine)

Enzymes