Showing metabocard for D-Galactose (BMDB0000143)

General function:

Carbohydrate transport and metabolism

Specific function:

Major enzyme for galactose metabolism.

Gene Name:

GALK1

Uniprot ID:

A6H768

Molecular weight:

42227.0

Reactions

General function:

Involved in 20-alpha-hydroxysteroid dehydrogenase activity

Specific function:

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).

Gene Name:

AKR1B1

Uniprot ID:

P16116

Molecular weight:

35919.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Essential for the degradation of glycogen in lysosomes (PubMed:10723725). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.

Gene Name:

GAA

Uniprot ID:

Q9MYM4

Molecular weight:

104757.0

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity).

Gene Name:

COLEC12

Uniprot ID:

A6QP79

Molecular weight:

81751.0

General function:

Carbohydrate transport and metabolism

Specific function:

Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense.

Gene Name:

CL43

Uniprot ID:

P42916

Molecular weight:

33616.0

General function:

Involved in lipid binding

Specific function:

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.

Gene Name:

APOC3

Uniprot ID:

P19035

Molecular weight:

10692.0

General function:

Not Available

Specific function:

Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity).

Gene Name:

NAGA

Uniprot ID:

Q58DH9

Molecular weight:

46533.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

LCT

Uniprot ID:

E1BK89

Molecular weight:

219131.0

Reactions