Showing metabocard for Inosine triphosphate (BMDB0000189)

General function:

Not Available

Specific function:

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity).

Gene Name:

ENTPD8

Uniprot ID:

A0JND9

Molecular weight:

53240.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).

Gene Name:

GMPR2

Uniprot ID:

Q32L93

Molecular weight:

38033.0

General function:

Nucleotide transport and metabolism

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Gene Name:

NME7

Uniprot ID:

Q5E9Y9

Molecular weight:

42599.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Gene Name:

ITPA

Uniprot ID:

Q2KIC5

Molecular weight:

23061.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Gene Name:

GMPR

Uniprot ID:

Q08DA2

Molecular weight:

37504.0

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Gene Name:

IMPDH2

Uniprot ID:

Q3SWY3

Molecular weight:

55763.0

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Gene Name:

IMPDH1

Uniprot ID:

A0JNA3

Molecular weight:

55424.0