Showing metabocard for Uridine diphosphategalactose (BMDB0000302)

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides (By similarity).

Gene Name:

GALNT6

Uniprot ID:

Q5EA41

Molecular weight:

71138.0

General function:

Involved in calcium ion binding

Specific function:

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.

Gene Name:

GALNT1

Uniprot ID:

Q07537

Molecular weight:

64192.0

General function:

Involved in glycoprotein-N-acetylgalactosamine 3-beta-g

Specific function:

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity).

Gene Name:

C1GALT1

Uniprot ID:

Q0VC84

Molecular weight:

43041.0

General function:

Involved in alpha-tubulin binding

Specific function:

The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Gene Name:

B4GALT1

Uniprot ID:

P08037

Molecular weight:

44843.0

Reactions

General function:

Involved in beta-N-acetylglucosaminylglycopeptide beta-

Specific function:

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Gene Name:

B4GALT3

Uniprot ID:

Q5EA87

Molecular weight:

44371.0

General function:

Involved in manganese ion binding

Specific function:

Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3).

Gene Name:

GGTA1

Uniprot ID:

P14769

Molecular weight:

43247.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

GALT

Uniprot ID:

Q0V7N7

Molecular weight:

37812.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

GALT

Uniprot ID:

Q58CX1

Molecular weight:

41288.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Gene Name:

LALBA

Uniprot ID:

P00711

Molecular weight:

16247.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.

Gene Name:

SLC35A2

Uniprot ID:

Q58DA6

Molecular weight:

41180.0

General function:

Not Available

Specific function:

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.

Gene Name:

GALE

Uniprot ID:

Q3T105

Molecular weight:

38254.0

Reactions