Showing metabocard for Dodecanoic acid (BMDB0000638)

General function:

Involved in carnitine O-octanoyltransferase activity

Specific function:

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.

Gene Name:

CROT

Uniprot ID:

O19094

Molecular weight:

70263.0

Reactions

General function:

Involved in carnitine O-palmitoyltransferase activity

Specific function:

Not Available

Gene Name:

CPT2

Uniprot ID:

Q2KJB7

Molecular weight:

74483.0

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.

Gene Name:

FASN

Uniprot ID:

Q71SP7

Molecular weight:

274554.0

Reactions

General function:

Lipid transport and metabolism

Specific function:

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754).

Gene Name:

ACSM1

Uniprot ID:

Q9BEA2

Molecular weight:

64923.0

Reactions

General function:

Involved in G-protein coupled receptor activity

Specific function:

Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity).

Gene Name:

GPR84

Uniprot ID:

Q2KI97

Molecular weight:

43517.0