Showing metabocard for L-Glutamine (BMDB0000641)

General function:

Amino acid transport and metabolism

Specific function:

Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity).

Gene Name:

GLUL

Uniprot ID:

P15103

Molecular weight:

42031.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ASNS

Uniprot ID:

Q1LZA3

Molecular weight:

64220.0

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (By similarity).

Gene Name:

GFPT2

Uniprot ID:

Q08DQ2

Molecular weight:

77081.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Gene Name:

QRSL1

Uniprot ID:

Q29RP9

Molecular weight:

57300.0

General function:

Involved in acyltransferase activity

Specific function:

Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.

Gene Name:

TGM2

Uniprot ID:

P51176

Molecular weight:

77112.0

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.

Gene Name:

NADSYN1

Uniprot ID:

Q3ZBF0

Molecular weight:

79400.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Glutamine--tRNA ligase. Plays a critical role in brain development.

Gene Name:

QARS1

Uniprot ID:

Q3MHH4

Molecular weight:

87643.0

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Gene Name:

F13A1

Uniprot ID:

P12260

Molecular weight:

22745.0

General function:

Involved in glycine N-acyltransferase activity

Specific function:

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Gene Name:

GLYAT

Uniprot ID:

Q2KIR7

Molecular weight:

33907.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity).

Gene Name:

SLC38A5

Uniprot ID:

Q5E9S9

Molecular weight:

51958.0

General function:

Involved in L-glutamine transmembrane transporter activity

Specific function:

Not Available

Gene Name:

SLC38A1

Uniprot ID:

B0LSH3

Molecular weight:

2372.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q866Q8

Molecular weight:

21625.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC38A3

Uniprot ID:

Q3MHG9

Molecular weight:

40823.0

General function:

Inorganic ion transport and metabolism

Specific function:

Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production.

Gene Name:

PQBP1

Uniprot ID:

Q2HJC9

Molecular weight:

30346.0

General function:

Involved in L-glutamine transmembrane transporter activity

Specific function:

Not Available

Gene Name:

SLC38A3

Uniprot ID:

B0LSH5

Molecular weight:

2581.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC38A3

Uniprot ID:

Q5BIN7

Molecular weight:

55315.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

CAD

Uniprot ID:

F1MVC0

Molecular weight:

243038.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

GLS2

Uniprot ID:

E1BHZ6

Molecular weight:

66700.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

PPAT

Uniprot ID:

F1MV22

Molecular weight:

59900.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

GMPS

Uniprot ID:

Q2T9U0

Molecular weight:

77865.0

Reactions