Showing metabocard for Hydroxyproline (BMDB0000725)

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

DDO

Uniprot ID:

P31228

Molecular weight:

37660.0

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

Gene Name:

P4HA1

Uniprot ID:

Q1RMU3

Molecular weight:

61010.0

General function:

Involved in iron ion binding

Specific function:

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

Gene Name:

P4HA3

Uniprot ID:

Q75UG4

Molecular weight:

61023.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Gene Name:

DPP4

Uniprot ID:

P81425

Molecular weight:

88369.0

General function:

Amino acid transport and metabolism

Specific function:

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).

Gene Name:

PYCR2

Uniprot ID:

Q17QJ7

Molecular weight:

33630.0

Reactions

General function:

Not Available

Specific function:

Converts proline to delta-1-pyrroline-5-carboxylate.

Gene Name:

PRODH

Uniprot ID:

Q148G5

Molecular weight:

67080.0

Reactions