Showing metabocard for Prostaglandin E2 (BMDB0001220)

General function:

Lipid transport and metabolism

Specific function:

Not Available

Gene Name:

HPGD

Uniprot ID:

Q309F3

Molecular weight:

29025.0

General function:

Lipid transport and metabolism

Specific function:

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity).

Gene Name:

CBR1

Uniprot ID:

Q3SZD7

Molecular weight:

30533.0

Reactions

General function:

Involved in prostaglandin E receptor activity

Specific function:

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity).

Gene Name:

PTGER4

Uniprot ID:

Q8MJ08

Molecular weight:

53298.0

General function:

Involved in prostaglandin E receptor activity

Specific function:

Not Available

Gene Name:

PTGER4

Uniprot ID:

Q1JPJ5

Molecular weight:

25029.0

General function:

Not Available

Specific function:

Receptor for prostaglandin E2 (PGE2) (PubMed:8396726). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p) (PubMed:8396726). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).

Gene Name:

PTGER3

Uniprot ID:

P34979

Molecular weight:

46362.0

General function:

Involved in prostaglandin E receptor activity

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q8MJ09

Molecular weight:

39726.0

General function:

Involved in prostaglandin E receptor activity

Specific function:

Not Available

Gene Name:

ep1

Uniprot ID:

Q95M52

Molecular weight:

3120.0

General function:

Involved in prostaglandin E receptor activity

Specific function:

Not Available

Gene Name:

ep4

Uniprot ID:

Q95M50

Molecular weight:

18505.0

General function:

Involved in prostaglandin E receptor activity

Specific function:

Not Available

Gene Name:

ep2

Uniprot ID:

Q95M51

Molecular weight:

15313.0

General function:

Not Available

Specific function:

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).

Gene Name:

PTGES

Uniprot ID:

Q95L14

Molecular weight:

17298.0

Reactions