Showing metabocard for 1-Pyrroline-5-carboxylic acid (BMDB0001301)

General function:

Energy production and conversion

Specific function:

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).

Gene Name:

ALDH4A1

Uniprot ID:

A7YWE4

Molecular weight:

61495.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.

Gene Name:

PRODH2

Uniprot ID:

A6QQ74

Molecular weight:

51262.0

General function:

Amino acid transport and metabolism

Specific function:

Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

Gene Name:

PYCR3

Uniprot ID:

Q58D08

Molecular weight:

32035.0

General function:

Amino acid transport and metabolism

Specific function:

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).

Gene Name:

PYCR2

Uniprot ID:

Q17QJ7

Molecular weight:

33630.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.

Gene Name:

PYCR1

Uniprot ID:

Q58DT4

Molecular weight:

33454.0

General function:

Not Available

Specific function:

Converts proline to delta-1-pyrroline-5-carboxylate.

Gene Name:

PRODH

Uniprot ID:

Q148G5

Molecular weight:

67080.0

Reactions