Showing metabocard for Citric acid (BMDB0000094)

General function:

Energy production and conversion

Specific function:

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.

Gene Name:

ACLY

Uniprot ID:

Q32PF2

Molecular weight:

119789.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

CS

Uniprot ID:

Q29RK1

Molecular weight:

51773.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).

Gene Name:

PFKL

Uniprot ID:

A1A4J1

Molecular weight:

85292.0

General function:

Energy production and conversion

Specific function:

Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.

Gene Name:

ACO1

Uniprot ID:

Q0VCU1

Molecular weight:

98204.0

Reactions

General function:

Energy production and conversion

Specific function:

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

Gene Name:

ACO2

Uniprot ID:

P20004

Molecular weight:

85359.0

Reactions

General function:

Involved in binding

Specific function:

Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation.

Gene Name:

SLC25A1

Uniprot ID:

P79110

Molecular weight:

33876.0