Showing metabocard for Glycerol (BMDB0000131)

General function:

Involved in heparin binding

Specific function:

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity).

Gene Name:

LIPC

Uniprot ID:

Q3SZ79

Molecular weight:

56826.0

Reactions

General function:

Involved in 20-alpha-hydroxysteroid dehydrogenase activity

Specific function:

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).

Gene Name:

AKR1B1

Uniprot ID:

P16116

Molecular weight:

35919.0

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General function:

Energy production and conversion

Specific function:

Key enzyme in the regulation of glycerol uptake and metabolism.

Gene Name:

GK

Uniprot ID:

Q0IID9

Molecular weight:

61261.0

Reactions

General function:

Transcription

Specific function:

Not Available

Gene Name:

GK5

Uniprot ID:

Q08D86

Molecular weight:

58765.0

General function:

Involved in calcium ion binding

Specific function:

Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Gene Name:

DGKA

Uniprot ID:

A0JN54

Molecular weight:

82672.0

General function:

Involved in acylglycerol lipase activity

Specific function:

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity).

Gene Name:

ABHD6

Uniprot ID:

Q1LZ86

Molecular weight:

38353.0

General function:

Lipid transport and metabolism

Specific function:

In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Gene Name:

LIPE

Uniprot ID:

P16386

Molecular weight:

82641.0

General function:

Involved in acylglycerol lipase activity

Specific function:

Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).

Gene Name:

ABHD12

Uniprot ID:

Q08DW9

Molecular weight:

45220.0

General function:

Not Available

Specific function:

Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity).

Gene Name:

NAGA

Uniprot ID:

Q58DH9

Molecular weight:

46533.0

Reactions