Showing metabocard for L-Proline (BMDB0000162)

General function:

Amino acid transport and metabolism

Specific function:

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Gene Name:

LAP3

Uniprot ID:

P00727

Molecular weight:

56289.0

General function:

Amino acid transport and metabolism

Specific function:

Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity).

Gene Name:

XPNPEP1

Uniprot ID:

Q1JPJ2

Molecular weight:

69790.0

General function:

Involved in iron ion binding

Specific function:

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

Gene Name:

P4HA1

Uniprot ID:

Q1RMU3

Molecular weight:

61010.0

General function:

Involved in iron ion binding

Specific function:

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

Gene Name:

P4HA3

Uniprot ID:

Q75UG4

Molecular weight:

61023.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.

Gene Name:

PRODH2

Uniprot ID:

A6QQ74

Molecular weight:

51262.0

General function:

Involved in proline racemase activity

Specific function:

Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C).

Gene Name:

L3HYPDH

Uniprot ID:

Q3SX04

Molecular weight:

37957.0

General function:

Amino acid transport and metabolism

Specific function:

Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

Gene Name:

PYCR3

Uniprot ID:

Q58D08

Molecular weight:

32035.0

General function:

Amino acid transport and metabolism

Specific function:

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).

Gene Name:

PYCR2

Uniprot ID:

Q17QJ7

Molecular weight:

33630.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.

Gene Name:

PYCR1

Uniprot ID:

Q58DT4

Molecular weight:

33454.0

General function:

Involved in cysteine-type endopeptidase activity

Specific function:

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity).

Gene Name:

CTSZ

Uniprot ID:

P05689

Molecular weight:

33886.0

General function:

Not Available

Specific function:

Converts proline to delta-1-pyrroline-5-carboxylate.

Gene Name:

PRODH

Uniprot ID:

Q148G5

Molecular weight:

67080.0

Reactions