Bovine Metabolome Database: Showing metabocard for L-Serine (BMDB0000187)

Identification Taxonomy Physical properties Pathways Spectra Concentrations Links References enzymes (12) Show 12 proteins XML

Record Information

Version

1.0

Creation Date

2016-09-30 22:26:27 UTC

Update Date

2020-06-04 22:19:12 UTC

BMDB ID

BMDB0000187

Secondary Accession Numbers

BMDB00187

Metabolite Identification

Common Name

L-Serine

Description

L-Serine, also known as (S)-serine or L-ser, belongs to the class of organic compounds known as serine and derivatives. Serine and derivatives are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. L-Serine is a drug which is used as a natural moisturizing agent in some cosmetics and skin care products. L-Serine exists as a solid, possibly soluble (in water), and a very strong basic compound (based on its pKa) molecule. L-Serine exists in all living species, ranging from bacteria to humans. L-Serine is a potentially toxic compound.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-3-hydroxypropanoic acid	ChEBI
(S)-(-)-Serine	ChEBI
(S)-2-Amino-3-hydroxypropanoic acid	ChEBI
(S)-alpha-Amino-beta-hydroxypropionic acid	ChEBI
(S)-Serine	ChEBI
beta-Hydroxy-L-alanine	ChEBI
beta-Hydroxyalanine	ChEBI
L-(-)-Serine	ChEBI
L-2-Amino-3-hydroxypropionic acid	ChEBI
L-3-Hydroxy-2-aminopropionic acid	ChEBI
L-3-Hydroxy-alanine	ChEBI
L-Ser	ChEBI
L-Serin	ChEBI
S	ChEBI
Ser	ChEBI
SERINE	ChEBI
(2S)-2-Amino-3-hydroxypropanoate	Generator
(S)-2-Amino-3-hydroxypropanoate	Generator
(S)-a-Amino-b-hydroxypropionate	Generator
(S)-a-Amino-b-hydroxypropionic acid	Generator
(S)-alpha-Amino-beta-hydroxypropionate	Generator
(S)-Α-amino-β-hydroxypropionate	Generator
(S)-Α-amino-β-hydroxypropionic acid	Generator
b-Hydroxy-L-alanine	Generator
Β-hydroxy-L-alanine	Generator
b-Hydroxyalanine	Generator
Β-hydroxyalanine	Generator
L-2-Amino-3-hydroxypropionate	Generator
L-3-Hydroxy-2-aminopropionate	Generator
(-)-Serine	HMDB
(S)-2-Amino-3-hydroxy-propanoate	HMDB
(S)-2-Amino-3-hydroxy-propanoic acid	HMDB
(S)-b-Amino-3-hydroxypropionate	HMDB
(S)-b-Amino-3-hydroxypropionic acid	HMDB
(S)-beta-Amino-3-hydroxypropionate	HMDB
(S)-beta-Amino-3-hydroxypropionic acid	HMDB
2-Amino-3-hydroxypropanoate	HMDB
2-Amino-3-hydroxypropanoic acid	HMDB
3-Hydroxy-L-alanine	HMDB
L Serine	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-BETA,BETA-carotene-3,3'-diol	HMDB
Bo-xan	HMDB
e 161b	HMDB
Xanthophyll	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3'-diol	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3'-diol	HMDB

Chemical Formula

C₃H₇NO₃

Average Molecular Weight

105.0926

Monoisotopic Molecular Weight

105.042593095

IUPAC Name

(2S)-2-amino-3-hydroxypropanoic acid

Traditional Name

L-serine

CAS Registry Number

56-45-1

SMILES

N[C@@H](CO)C(O)=O

InChI Identifier

InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

InChI Key

MTCFGRXMJLQNBG-REOHCLBHSA-N

Chemical Taxonomy

Description

belongs to the class of organic compounds known as serine and derivatives. Serine and derivatives are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Serine and derivatives

Alternative Parents

Substituents

Serine or derivatives
Alpha-amino acid
L-alpha-amino acid
Beta-hydroxy acid
Hydroxy acid
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Alcohol
Primary amine
Primary alcohol
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Primary aliphatic amine
Organic oxide
Organopnictogen compound
Carbonyl group
Organic oxygen compound
Amine
Organic nitrogen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:17115 )
L-alpha-amino acid (CHEBI:17115 )
serine (CHEBI:17115 )
serine family amino acid (CHEBI:17115 )
Common amino acids (C00065 )

Ontology

Status

Detected and Quantified

Origin

Endogenous

Biofunction

Not Available

Application

Not Available

Cellular locations

Cytoplasm
Mitochondria
Peroxisome

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	228 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	425.0 mg/mL	Not Available
LogP	-3.07	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-3.4	ALOGPS
logP	-3.9	ChemAxon
logS	0.66	ALOGPS
pKa (Strongest Acidic)	2.03	ChemAxon
pKa (Strongest Basic)	8.93	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	83.55 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	22.04 m³·mol⁻¹	ChemAxon
Polarizability	9.39 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Spectrum Type	Description	Splash Key
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-0udi-0940000000-59d5e0f76fd204be8110	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-0udi-0980000000-ab49fc3ee88db87d1a16	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (2 TMS)	splash10-0159-0900000000-8e169037bcbe1dcd5de8	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-0uxr-0970000000-67271ed235e35c662db5	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-00di-9540000000-1297bf302358bcf0f1c0	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-0uxr-1790000000-caaa37778f5a4686f5f0	View in MoNA
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-0159-0900000000-ae4f860052c41e9ba734	View in MoNA
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-0uxr-0590000000-ce32a8bfb64d16590b52	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0udi-0940000000-59d5e0f76fd204be8110	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0udi-0980000000-ab49fc3ee88db87d1a16	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0159-0900000000-8e169037bcbe1dcd5de8	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0uxr-0970000000-67271ed235e35c662db5	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-QQ (Non-derivatized)	splash10-00dr-7966000000-7b5b37fd4ac885548172	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-9540000000-1297bf302358bcf0f1c0	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-0uxr-1790000000-caaa37778f5a4686f5f0	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-06sl-9000000000-033631650075b940e0e2	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive	splash10-0fkl-9420000000-ed7a327e1f071802a4dd	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	View in JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	View in JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	View in JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	View in JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	View in JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_2) - 70eV, Positive	Not Available	View in JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_3) - 70eV, Positive	Not Available	View in JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_4) - 70eV, Positive	Not Available	View in JSpectraViewer
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-03di-9100000000-38f84912ebfc7b4e8339	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-03dl-9000000000-89e57995d3ca765a20e8	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-01ox-9100000000-f3baf93032cc9f09cf2d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0zfr-0900000000-b6085e53e881cdaa1824	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-2e16e9d6f9b3c2688f8a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-9857daa028fb3016a7e2	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0006-0009200000-0617acd25c69bf24ad1f	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-823dfcf6229956372e31	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-eec63565f8a9fe4bd336	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-008412efd202c202d56a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0930000000-932aedc4efb5e1dd5e7b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0w29-0951000000-cd0895e475dd50e4934d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-9000000000-15294ba22b153cf5ab5b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-014i-9000000000-48c370acff657443f0e6	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0190000000-1bad10ba7388ce0c2249	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0ue9-0792100000-9f2bfe40e4c01044d209	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-9000000000-dfa7aca58cc28303ebc7	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0900000000-282f31d8021649afdbe8	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0290000000-eeee98e6b0514b08cd63	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0udi-1900000000-ed66566e27a94ee99f13	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-00di-9100000000-b9f6b4b6ee7c88a9c569	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-00di-9000000000-929aea63ace0e20c6d43	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-00di-9000000000-ba9cd5b3e37ded5d3764	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0a4i-6900000000-5622633ab0a27d2e5360	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-03di-9000000000-3e25ca80e2e62be19ac5	View in MoNA
MS	Mass Spectrum (Electron Ionization)	splash10-0200-9000000000-dc5e2afcfab602641180	View in MoNA
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Not Available	View in JSpectraViewer
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Not Available	View in JSpectraViewer
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Not Available	View in JSpectraViewer

Biological Properties

Cellular Locations

Cytoplasm
Mitochondria
Peroxisome

Biospecimen Locations

All Tissues
Blood
Colostrum
Liver
Longissimus Thoracis Muscle
Mammary Gland
Milk
Muscle
Placenta
Prostate Tissue
Ruminal Fluid
Semen
Semimembranosus Muscle
Testis

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylethanolamine Biosynthesis		Not Available
Phosphatidylethanolamine Biosynthesis PE(14:0/14:0)		Not Available
Phosphatidylethanolamine Biosynthesis PE(14:0/14:1(9Z))		Not Available
Phosphatidylethanolamine Biosynthesis PE(14:0/15:0)		Not Available
Phosphatidylethanolamine Biosynthesis PE(14:0/16:0)		Not Available

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
All Tissues	Expected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	Not Applicable	details
Blood	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 25372282	details
Blood	Detected and Quantified	58.4 uM	Not Specified	Not Specified	Normal	PMID: 17197001	details
Blood	Detected and Quantified	71-84 uM	Not Specified	Not Specified	Normal	PMID: 11204708	details
Blood	Detected and Quantified	80.2 uM	Not Specified	Both	Normal	PMID: 9374324	details
Blood	Detected and Quantified	57-84 uM	Not Specified	Not Specified	Normal	PMID: 3535614	details
Blood	Detected and Quantified	86-89 uM	Not Specified	Not Specified	Normal	PMID: 28036059	details
Blood	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 24630653	details
Blood	Detected and Quantified	85 +/- 14 uM	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Colostrum	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 22361340	details
Liver	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 31873721	details
Liver	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 31873721	details
Liver	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 31867104	details
Liver	Detected and Quantified	422 +/- 114 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Longissimus Thoracis Muscle	Detected and Quantified	165 +/- 36 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Mammary Gland	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 31873721	details
Mammary Gland	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 31873721	details
Milk	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 25108860	details
Milk	Detected and Quantified	15 +/- 1 uM	Not Specified	Not Specified	Normal	PMID: 30994344	details
Milk	Detected and Quantified	18 +/- 1 uM	Not Specified	Not Specified	Normal	PMID: 30994344	details
Milk	Detected and Quantified	15.7 +/- 0.2 uM	Not Specified	Not Specified	Normal	PMID: 30994344	details
Milk	Detected and Quantified	15 +/- 1 uM	Not Specified	Not Specified	Normal	PMID: 30994344	details
Milk	Detected and Quantified	19030.836 uM	Not Specified	Not Specified	Normal	Fooddata+, T...	details
Milk	Detected and Quantified	19030.836 uM	Not Specified	Not Specified	Normal	Fooddata+, T...	details
Milk	Detected and Quantified	19030.836 uM	Not Specified	Not Specified	Normal	Fooddata+, T...	details
Milk	Detected and Quantified	19030.836 uM	Not Specified	Not Specified	Normal	Fooddata+, T...	details
Milk	Detected and Quantified	18079.294 uM	Not Specified	Not Specified	Normal	Fooddata+, T...	details
Milk	Detected and Quantified	18079.294 uM	Not Specified	Not Specified	Normal	Fooddata+, T...	details
Milk	Detected and Quantified	18079.294 uM	Not Specified	Not Specified	Normal	Fooddata+, T...	details
Muscle	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 22361340	details
Muscle	Detected and Quantified	273-830 nmol/g of tissue	Not Specified	Not Specified	Normal	PMID: 30744349	details
Placenta	Expected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	Not Applicable	details
Prostate Tissue	Expected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	Not Applicable	details
Ruminal Fluid	Detected and Quantified	50 +/- 14 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	85 +/- 29 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	123 +/- 57 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	49 +/- 25 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	49 +/- 25 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	45.29 +/- 23.71 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	547 +/- 187 uM	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Semen	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 5096119	details
Semen	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 31533629	details
Semen	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 29634739	details
Semimembranosus Muscle	Detected and Quantified	161 +/- 31 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Testis	Detected and Quantified	630-830 nmol/g of tissue	Not Specified	Not Specified	Normal	PMID: 4429492	details
Testis	Detected and Quantified	230 nmol/g of tissue	Not Specified	Not Specified	Normal	PMID: 5096119	details
Testis	Detected and Quantified	272 +/- 58 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	All Mycobacterium avium subsp. paratuberculosis-infected	PMID: 25372282	details
Blood	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	High dose Mycobacterium avium subsp. paratuberculosis-infected	PMID: 25372282	details
Blood	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Low dose Mycobacterium avium subsp. paratuberculosis-infected	PMID: 25372282	details
Blood	Detected and Quantified	61.5 uM	Not Specified	Not Specified	Bovine spongiform encephalopathy positive	PMID: 17197001	details
Blood	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Sub/clinical ketosis	PMID: 24070026	details
Blood	Detected and Quantified	66.7 uM	Not Specified	Not Specified	Bovine spongiform encephalopathy negative	PMID: 17197001	details
Colostrum	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Commercial Product/bacterial growth on ground beef	PMID: 22417363	details
Muscle	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Commercial Product/bacterial growth on ground beef	PMID: 22417363	details
Ruminal Fluid	Detected and Quantified	116.49 +/- 57.91 uM	Not Specified	Not Specified	Rumen acidosis	Fozia Saleem, Sou...	details

External Links

HMDB ID

HMDB0000187

DrugBank ID

DB00133

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

17115

References

Synthesis Reference

Qin, Wei-min; Cao, Fei; Zhou, Hua; Li, Zhen-jiang; Wei, Ping. Asymmetric synthesis of D- and L-serine with "Glycine equivalent" method. Huaxue Shiji (2005), 27(11), 643-644, 670.

Material Safety Data Sheet (MSDS)

Not Available

General References

Scano P, Murgia A, Pirisi FM, Caboni P: A gas chromatography-mass spectrometry-based metabolomic approach for the characterization of goat milk compared with cow milk. J Dairy Sci. 2014 Oct;97(10):6057-66. doi: 10.3168/jds.2014-8247. Epub 2014 Aug 6. [PubMed:25108860 ]
Mung D, Li L: Development of Chemical Isotope Labeling LC-MS for Milk Metabolomics: Comprehensive and Quantitative Profiling of the Amine/Phenol Submetabolome. Anal Chem. 2017 Apr 18;89(8):4435-4443. doi: 10.1021/acs.analchem.6b03737. Epub 2017 Mar 28. [PubMed:28306241 ]
Mung D, Li L: Applying quantitative metabolomics based on chemical isotope labeling LC-MS for detecting potential milk adulterant in human milk. Anal Chim Acta. 2018 Feb 25;1001:78-85. doi: 10.1016/j.aca.2017.11.019. Epub 2017 Nov 14. [PubMed:29291809 ]
A. Foroutan et al. (2019). A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation). Journal of Agricultural and Food Chemistry.
Fooddata+, The Technical University of Denmark (DTU) [Link]

Enzymes

Enzyme Details

1. Serine racemase

General function:: Amino acid transport and metabolism
Specific function:: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).
Gene Name:: SRR
Uniprot ID:: A0JNI4
Molecular weight:: 36181.0

Reactions

L-Serine → D-Serine	details

Enzyme Details

2. Serine hydroxymethyltransferase, mitochondrial

General function:: Amino acid transport and metabolism
Specific function:: Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.
Gene Name:: SHMT2
Uniprot ID:: Q3SZ20
Molecular weight:: 55605.0

Reactions

5,10-Methylene-THF + Glycine + Water → Tetrahydrofolic acid + L-Serine	details

Enzyme Details

3. Serine--tRNA ligase, mitochondrial

General function:: Translation, ribosomal structure and biogenesis
Specific function:: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Gene Name:: SARS2
Uniprot ID:: Q9N0F3
Molecular weight:: 58296.0

Reactions

L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphate	details

Enzyme Details

4. Serine palmitoyltransferase 1

General function:: Coenzyme transport and metabolism
Specific function:: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity).
Gene Name:: SPTLC1
Uniprot ID:: Q3MHG1
Molecular weight:: 52788.0

Reactions

Palmityl-CoA + L-Serine → 3-Dehydrosphinganine + Carbon dioxide	details

Enzyme Details

5. Serine--tRNA ligase, cytoplasmic

General function:: Translation, ribosomal structure and biogenesis
Specific function:: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Gene Name:: SARS1
Uniprot ID:: Q9GMB8
Molecular weight:: 58605.0

Reactions

L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphate	details

Enzyme Details

6. Serine hydroxymethyltransferase, cytosolic

General function:: Amino acid transport and metabolism
Specific function:: Interconversion of serine and glycine.
Gene Name:: SHMT1
Uniprot ID:: Q5E9P9
Molecular weight:: 52978.0

Reactions

L-Serine + Tetrahydrofolic acid → Glycine + 5,10-Methylene-THF + Water	details
Tetrahydrofolic acid + L-Serine → 5,10-Methylene-THF + Glycine + Water	details

Enzyme Details

7. L-serine dehydratase/L-threonine deaminase

General function:: Amino acid transport and metabolism
Specific function:: Not Available
Gene Name:: SDS
Uniprot ID:: Q0VCW4
Molecular weight:: 34441.0

Reactions

L-Serine → Pyruvic acid + Ammonia	details

Enzyme Details

8. 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

General function:: Coenzyme transport and metabolism
Specific function:: Not Available
Gene Name:: GCAT
Uniprot ID:: Q0P5L8
Molecular weight:: 45166.0

Reactions

Palmityl-CoA + L-Serine → 3-Dehydrosphinganine + Carbon dioxide	details

Enzyme Details

9. Phosphoserine phosphatase

General function:: Amino acid transport and metabolism
Specific function:: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity).
Gene Name:: PSPH
Uniprot ID:: Q2KHU0
Molecular weight:: 24850.0

Reactions

Phosphoserine + Water → L-Serine + Hydrogen phosphate	details

Enzyme Details

10. Serine--pyruvate aminotransferase

General function:: Amino acid transport and metabolism
Specific function:: Not Available
Gene Name:: AGXT
Uniprot ID:: A7MBF1
Molecular weight:: 45292.0

Reactions

Pyruvic acid + L-Serine → Hydroxypyruvic acid + L-Alanine	details

Enzyme Details

11. Phosphatidylserine synthase 1

General function:: Not Available
Specific function:: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
Gene Name:: PTDSS1
Uniprot ID:: Q2KHY9
Molecular weight:: 55416.0

Reactions

Phosphatidylcholine + L-Serine → an L-1-Phosphatidylserine + Choline	details
PC(14:0/14:0) + L-Serine → Choline + PS(14:0/14:0)	details
PC(14:0/14:1(9Z)) + L-Serine → Choline + PS(14:0/14:1(9Z))	details
PC(14:0/16:0) + L-Serine → Choline + PS(14:0/16:0)	details
PC(14:0/16:1(9Z)) + L-Serine → Choline + PS(14:0/16:1(9Z))	details
PC(14:0/18:0) + L-Serine → Choline + PS(14:0/18:0)	details
PC(14:0/18:1(9Z)) + L-Serine → Choline + PS(14:0/18:1(9Z))	details
PC(14:0/18:2(9Z,12Z)) + L-Serine → Choline + PS(14:0/18:2(9Z,12Z))	details
PC(14:0/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(14:0/18:3(9Z,12Z,15Z))	details
PC(14:0/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(14:0/20:3(8Z,11Z,14Z))	details
PC(14:0/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(14:0/20:4(5Z,8Z,11Z,14Z))	details
PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(14:1(9Z)/14:1(9Z)) + L-Serine → Choline + PS(14:1(9Z)/14:1(9Z))	details
PC(14:1(9Z)/16:0) + L-Serine → Choline + PS(14:1(9Z)/16:0)	details
PC(14:1(9Z)/16:1(9Z)) + L-Serine → Choline + PS(14:1(9Z)/16:1(9Z))	details
PC(14:1(9Z)/18:0) + L-Serine → Choline + PS(14:1(9Z)/18:0)	details
PC(14:1(9Z)/18:1(9Z)) + L-Serine → Choline + PS(14:1(9Z)/18:1(9Z))	details
PC(14:1(9Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(14:1(9Z)/18:2(9Z,12Z))	details
PC(14:1(9Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(14:1(9Z)/18:3(9Z,12Z,15Z))	details
PC(14:1(9Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(14:1(9Z)/20:3(8Z,11Z,14Z))	details
PC(14:1(9Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(14:1(9Z)/20:4(5Z,8Z,11Z,14Z))	details
PC(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(16:0/16:1(9Z)) + L-Serine → Choline + PS(16:0/16:1(9Z))	details
PC(16:0/18:0) + L-Serine → Choline + PS(16:0/18:0)	details
PC(16:0/18:1(11Z)) + L-Serine → Choline + PS(16:0/18:1(11Z))	details
PC(16:0/18:1(9Z)) + L-Serine → Choline + PS(16:0/18:1(9Z))	details
PC(16:0/18:2(9Z,12Z)) + L-Serine → Choline + PS(16:0/18:2(9Z,12Z))	details
PC(16:0/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(16:0/18:3(6Z,9Z,12Z))	details
PC(16:0/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(16:0/18:3(9Z,12Z,15Z))	details
PC(16:0/20:0) + L-Serine → Choline + PS(16:0/20:0)	details
PC(16:0/20:1(11Z)) + L-Serine → Choline + PS(16:0/20:1(11Z))	details
PC(16:0/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(16:0/20:3(8Z,11Z,14Z))	details
PC(16:0/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(16:0/20:4(5Z,8Z,11Z,14Z))	details
PC(16:0/22:0) + L-Serine → Choline + PS(16:0/22:0)	details
PC(16:0/22:1(13Z)) + L-Serine → Choline + PS(16:0/22:1(13Z))	details
PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(16:1(9Z)/16:1(9Z)) + L-Serine → Choline + PS(16:1(9Z)/16:1(9Z))	details
PC(16:1(9Z)/18:0) + L-Serine → Choline + PS(16:1(9Z)/18:0)	details
PC(16:1(9Z)/18:1(9Z)) + L-Serine → Choline + PS(16:1(9Z)/18:1(9Z))	details
PC(16:1(9Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(16:1(9Z)/18:2(9Z,12Z))	details
PC(16:1(9Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(16:1(9Z)/18:3(9Z,12Z,15Z))	details
PC(16:1(9Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(16:1(9Z)/20:3(8Z,11Z,14Z))	details
PC(16:1(9Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(16:1(9Z)/20:4(5Z,8Z,11Z,14Z))	details
PC(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(18:0/18:0) + L-Serine → Choline + PS(18:0/18:0)	details
PC(18:0/18:1(11Z)) + L-Serine → Choline + PS(18:0/18:1(11Z))	details
PC(18:0/18:1(9Z)) + L-Serine → Choline + PS(18:0/18:1(9Z))	details
PC(18:0/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:0/18:2(9Z,12Z))	details
PC(18:0/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:0/18:3(6Z,9Z,12Z))	details
PC(18:0/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:0/18:3(9Z,12Z,15Z))	details
PC(18:0/20:0) + L-Serine → Choline + PS(18:0/20:0)	details
PC(18:0/20:1(11Z)) + L-Serine → Choline + PS(18:0/20:1(11Z))	details
PC(18:0/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:0/20:3(8Z,11Z,14Z))	details
PC(18:0/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:0/20:4(5Z,8Z,11Z,14Z))	details
PC(18:0/20:4(8Z,11Z,14Z,17Z)) + L-Serine → Choline + PS(18:0/20:4(8Z,11Z,14Z,17Z))	details
PC(18:0/22:0) + L-Serine → Choline + PS(18:0/22:0)	details
PC(18:0/22:1(13Z)) + L-Serine → Choline + PS(18:0/22:1(13Z))	details
PC(18:0/22:5(7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:0/22:5(7Z,10Z,13Z,16Z,19Z))	details
PC(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(18:1(11Z)/18:1(11Z)) + L-Serine → Choline + PS(18:1(11Z)/18:1(11Z))	details
PC(18:1(11Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:1(11Z)/18:2(9Z,12Z))	details
PC(18:1(11Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:1(11Z)/18:3(6Z,9Z,12Z))	details
PC(18:1(11Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:1(11Z)/18:3(9Z,12Z,15Z))	details
PC(18:1(11Z)/20:0) + L-Serine → Choline + PS(18:1(11Z)/20:0)	details
PC(18:1(11Z)/20:1(11Z)) + L-Serine → Choline + PS(18:1(11Z)/20:1(11Z))	details
PC(18:1(11Z)/22:0) + L-Serine → Choline + PS(18:1(11Z)/22:0)	details
PC(18:1(11Z)/22:1(13Z)) + L-Serine → Choline + PS(18:1(11Z)/22:1(13Z))	details
PC(18:1(9Z)/18:1(9Z)) + L-Serine → Choline + PS(18:1(9Z)/18:1(9Z))	details
PC(18:1(9Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:1(9Z)/18:2(9Z,12Z))	details
PC(18:1(9Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:1(9Z)/18:3(6Z,9Z,12Z))	details
PC(18:1(9Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:1(9Z)/18:3(9Z,12Z,15Z))	details
PC(18:1(9Z)/20:0) + L-Serine → Choline + PS(18:1(9Z)/20:0)	details
PC(18:1(9Z)/20:1(11Z)) + L-Serine → Choline + PS(18:1(9Z)/20:1(11Z))	details
PC(18:1(9Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:1(9Z)/20:3(8Z,11Z,14Z))	details
PC(18:1(9Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:1(9Z)/20:4(5Z,8Z,11Z,14Z))	details
PC(18:1(9Z)/22:0) + L-Serine → Choline + PS(18:1(9Z)/22:0)	details
PC(18:1(9Z)/22:1(13Z)) + L-Serine → Choline + PS(18:1(9Z)/22:1(13Z))	details
PC(18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(18:2(9Z,12Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/18:2(9Z,12Z))	details
PC(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/18:3(6Z,9Z,12Z))	details
PC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))	details
PC(18:2(9Z,12Z)/20:0) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:0)	details
PC(18:2(9Z,12Z)/20:1(11Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:1(11Z))	details
PC(18:2(9Z,12Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:3(8Z,11Z,14Z))	details
PC(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))	details
PC(18:2(9Z,12Z)/22:0) + L-Serine → Choline + PS(18:2(9Z,12Z)/22:0)	details
PC(18:2(9Z,12Z)/22:1(13Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/22:1(13Z))	details
PC(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z))	details
PC(18:3(6Z,9Z,12Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/18:3(9Z,12Z,15Z))	details
PC(18:3(6Z,9Z,12Z)/20:0) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/20:0)	details
PC(18:3(6Z,9Z,12Z)/20:1(11Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/20:1(11Z))	details
PC(18:3(6Z,9Z,12Z)/22:0) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/22:0)	details
PC(18:3(6Z,9Z,12Z)/22:1(13Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/22:1(13Z))	details
PC(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z))	details
PC(18:3(9Z,12Z,15Z)/20:0) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:0)	details
PC(18:3(9Z,12Z,15Z)/20:1(11Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:1(11Z))	details
PC(18:3(9Z,12Z,15Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:3(8Z,11Z,14Z))	details
PC(18:3(9Z,12Z,15Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:4(5Z,8Z,11Z,14Z))	details
PC(18:3(9Z,12Z,15Z)/22:0) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/22:0)	details
PC(18:3(9Z,12Z,15Z)/22:1(13Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/22:1(13Z))	details
PC(18:3(9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(20:0/20:0) + L-Serine → Choline + PS(20:0/20:0)	details
PC(20:0/20:1(11Z)) + L-Serine → Choline + PS(20:0/20:1(11Z))	details
PC(20:0/22:0) + L-Serine → Choline + PS(20:0/22:0)	details
PC(20:0/22:1(13Z)) + L-Serine → Choline + PS(20:0/22:1(13Z))	details
PC(20:1(11Z)/20:1(11Z)) + L-Serine → Choline + PS(20:1(11Z)/20:1(11Z))	details
PC(20:1(11Z)/22:0) + L-Serine → Choline + PS(20:1(11Z)/22:0)	details
PC(20:1(11Z)/22:1(13Z)) + L-Serine → Choline + PS(20:1(11Z)/22:1(13Z))	details
PC(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z))	details
PC(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))	details
PC(20:3(8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(20:3(8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))	details
PC(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details
PC(22:0/22:0) + L-Serine → Choline + PS(22:0/22:0)	details
PC(22:0/22:1(13Z)) + L-Serine → Choline + PS(22:0/22:1(13Z))	details
PC(22:1(13Z)/22:1(13Z)) + L-Serine → Choline + PS(22:1(13Z)/22:1(13Z))	details
PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	details

Enzyme Details

12. Cystathionine beta-synthase

General function:: Not Available
Specific function:: Not Available
Gene Name:: CBS
Uniprot ID:: F1MEW4
Molecular weight:: 62867.0

Reactions

L-Serine + Selenohomocysteine → Selenocystathionine + Water	details
Homocysteine + L-Serine → Water + L-Cystathionine	details
L-Homoserine + L-Serine → L-Cystathionine + Water	details

Showing metabocard for L-Serine (BMDB0000187)

Structure for BMDB0000187 (L-Serine)

Enzymes

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