Showing metabocard for Serotonin (BMDB0000259)

General function:

Involved in phenylethanolamine N-methyltransferase acti

Specific function:

Converts noradrenaline to adrenaline.

Gene Name:

PNMT

Uniprot ID:

P10938

Molecular weight:

30918.0

Reactions

General function:

Transcription

Specific function:

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

Gene Name:

AANAT

Uniprot ID:

O02785

Molecular weight:

22997.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Gene Name:

DDC

Uniprot ID:

P27718

Molecular weight:

54294.0

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

Gene Name:

SLC18A2

Uniprot ID:

Q27963

Molecular weight:

55756.0

General function:

Involved in G-protein coupled receptor activity

Specific function:

Not Available

Gene Name:

5htr2a

Uniprot ID:

Q8MI10

Molecular weight:

12090.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

5htr4

Uniprot ID:

Q8MI07

Molecular weight:

8014.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

5htr1a

Uniprot ID:

Q8MI15

Molecular weight:

7455.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

5htr1e

Uniprot ID:

Q8MI12

Molecular weight:

7133.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

HTR1B

Uniprot ID:

A1Y9Q2

Molecular weight:

11394.0

General function:

Involved in G-protein coupled receptor activity

Specific function:

Not Available

Gene Name:

5htr1f

Uniprot ID:

Q8MI11

Molecular weight:

9419.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

5htr2b

Uniprot ID:

Q8MI09

Molecular weight:

15560.0

General function:

Involved in serotonin receptor activity

Specific function:

Not Available

Gene Name:

HTR1B

Uniprot ID:

A1Y9Q0

Molecular weight:

10508.0

General function:

Involved in G-protein coupled receptor activity

Specific function:

Not Available

Gene Name:

HTR4

Uniprot ID:

Q5E9Q5

Molecular weight:

45366.0

General function:

Involved in serotonin:sodium symporter activity

Specific function:

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Gene Name:

SLC6A4

Uniprot ID:

Q9XT49

Molecular weight:

70036.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

HTR1B

Uniprot ID:

A1Y9Q3

Molecular weight:

13774.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

5htr1b

Uniprot ID:

Q8MI14

Molecular weight:

9284.0

General function:

Involved in serotonin receptor activity

Specific function:

Not Available

Gene Name:

HTR1B

Uniprot ID:

A1Y9P9

Molecular weight:

10524.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

5htr1d

Uniprot ID:

Q8MI13

Molecular weight:

12730.0

General function:

Involved in G-protein coupled receptor activity

Specific function:

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).

Gene Name:

HTR2A

Uniprot ID:

Q75Z89

Molecular weight:

52571.0

General function:

Involved in G-protein coupled receptor activity

Specific function:

Not Available

Gene Name:

5htr2c

Uniprot ID:

Q8MI08

Molecular weight:

9481.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

HTR1B

Uniprot ID:

A1Y9Q1

Molecular weight:

12690.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

KMO

Uniprot ID:

E1BN59

Molecular weight:

51032.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

IDO1

Uniprot ID:

F1N7C5

Molecular weight:

50061.0

Reactions