Showing metabocard for Succinyl-CoA (BMDB0001022)

General function:

Lipid transport and metabolism

Specific function:

Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle.

Gene Name:

MMUT

Uniprot ID:

Q9GK13

Molecular weight:

83235.0

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Not Available

Gene Name:

ALAS1

Uniprot ID:

A6QLI6

Molecular weight:

71062.0

Reactions

General function:

Energy production and conversion

Specific function:

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Gene Name:

SUCLA2

Uniprot ID:

Q148D5

Molecular weight:

50130.0

General function:

Energy production and conversion

Specific function:

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

Gene Name:

SUCLG1

Uniprot ID:

Q58DR8

Molecular weight:

36167.0

Reactions

General function:

Energy production and conversion

Specific function:

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Gene Name:

SUCLG2

Uniprot ID:

Q3MHX5

Molecular weight:

46691.0

Reactions

General function:

Energy production and conversion

Specific function:

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity).

Gene Name:

DLST

Uniprot ID:

P11179

Molecular weight:

48973.0

General function:

Coenzyme transport and metabolism

Specific function:

Not Available

Gene Name:

ALAS2

Uniprot ID:

Q3ZC31

Molecular weight:

65137.0

General function:

Not Available

Specific function:

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

Gene Name:

OXCT1

Uniprot ID:

Q24JZ7

Molecular weight:

56453.0

Reactions