Showing metabocard for Adenosine diphosphate ribose (BMDB0001178)

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.

Gene Name:

ADPRS

Uniprot ID:

Q3SYV9

Molecular weight:

39221.0

General function:

Involved in ADP-ribose diphosphatase activity

Specific function:

Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

Gene Name:

ADPRM

Uniprot ID:

A7YY53

Molecular weight:

39235.0

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.

Gene Name:

ADPRH

Uniprot ID:

Q32KR8

Molecular weight:

39152.0

General function:

Involved in poly(ADP-ribose) glycohydrolase activity

Specific function:

Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15658938). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity).

Gene Name:

PARG

Uniprot ID:

O02776

Molecular weight:

110837.0

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

Gene Name:

TRPT1

Uniprot ID:

Q3ZBM7

Molecular weight:

27791.0

General function:

Carbohydrate transport and metabolism

Specific function:

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity (By similarity).

Gene Name:

NAGK

Uniprot ID:

Q3SZM9

Molecular weight:

37268.0

Reactions

General function:

Involved in ADP binding

Specific function:

Not Available

Gene Name:

GCLC

Uniprot ID:

Q32S38

Molecular weight:

69023.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

GCLM

Uniprot ID:

Q2T9Y6

Molecular weight:

30533.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

NUDT5

Uniprot ID:

F1MMR8

Molecular weight:

18648.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

BST1

Uniprot ID:

F1MLP3

Molecular weight:

35144.0

Reactions