Showing metabocard for NADH (BMDB0001487)

General function:

Coenzyme transport and metabolism

Specific function:

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity).

Gene Name:

CYB5R4

Uniprot ID:

Q32LH7

Molecular weight:

59274.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

NDUFS7

Uniprot ID:

P42026

Molecular weight:

23771.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

NDUFS2

Uniprot ID:

P17694

Molecular weight:

52556.0

General function:

Carbohydrate transport and metabolism

Specific function:

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).

Gene Name:

GAPDH

Uniprot ID:

P10096

Molecular weight:

35868.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).

Gene Name:

GAPDHS

Uniprot ID:

Q2KJE5

Molecular weight:

43288.0

General function:

Lipid transport and metabolism

Specific function:

Not Available

Gene Name:

CRYL1

Uniprot ID:

Q8SPX7

Molecular weight:

35072.0

General function:

Energy production and conversion

Specific function:

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

Gene Name:

ALDH6A1

Uniprot ID:

Q07536

Molecular weight:

58063.0

Reactions

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

C5IX89

Molecular weight:

68329.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

MT-ND1

Uniprot ID:

P03887

Molecular weight:

35670.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4

Uniprot ID:

Q45LU7

Molecular weight:

52058.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4

Uniprot ID:

Q6JTG2

Molecular weight:

53800.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

C5IXE1

Molecular weight:

68117.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND2

Uniprot ID:

B1NZU0

Molecular weight:

39284.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q45M50

Molecular weight:

68155.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q45MI0

Molecular weight:

68316.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q3L5H4

Molecular weight:

68270.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q45LG6

Molecular weight:

68285.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

B1NZ26

Molecular weight:

68270.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

NDUFV2

Uniprot ID:

P04394

Molecular weight:

27308.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q8HBP4

Molecular weight:

33068.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

B1P0B8

Molecular weight:

68316.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ND1

Uniprot ID:

B1P0I6

Molecular weight:

35652.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND2

Uniprot ID:

Q6JTH0

Molecular weight:

39226.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ND1

Uniprot ID:

Q45MJ0

Molecular weight:

35661.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q7JAL5

Molecular weight:

68286.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4

Uniprot ID:

Q8HC63

Molecular weight:

15084.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ND1

Uniprot ID:

Q6QTH1

Molecular weight:

35656.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ND1

Uniprot ID:

Q45MC5

Molecular weight:

35700.0

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND6

Uniprot ID:

Q7JAS5

Molecular weight:

19078.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q8HC24

Molecular weight:

32995.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

B1P0J6

Molecular weight:

68201.0

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4L

Uniprot ID:

Q3L5T0

Molecular weight:

10765.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4

Uniprot ID:

C5IX88

Molecular weight:

52085.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ND1

Uniprot ID:

Q3L5J7

Molecular weight:

35636.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND6

Uniprot ID:

Q85UJ0

Molecular weight:

19044.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4

Uniprot ID:

B1P078

Molecular weight:

52113.0

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND6

Uniprot ID:

B1P0N6

Molecular weight:

19018.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND3

Uniprot ID:

Q7JAS9

Molecular weight:

13055.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

B1P092

Molecular weight:

68272.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4

Uniprot ID:

Q45MX4

Molecular weight:

52129.0

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

MT-ND6

Uniprot ID:

P03924

Molecular weight:

19078.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

B1P0N5

Molecular weight:

68175.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND4

Uniprot ID:

Q6JTD6

Molecular weight:

53814.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND5

Uniprot ID:

Q45LK5

Molecular weight:

68313.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND6

Uniprot ID:

B1NZ92

Molecular weight:

19106.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ND5

Uniprot ID:

A4ZI01

Molecular weight:

11807.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

MT-ND5

Uniprot ID:

P03920

Molecular weight:

68286.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q85E90

Molecular weight:

7295.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.

Gene Name:

NDUFS1

Uniprot ID:

P15690

Molecular weight:

79442.0

General function:

Energy production and conversion

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Name:

ND2

Uniprot ID:

Q45M46

Molecular weight:

39220.0