Showing metabocard for Progesterone (BMDB0001830)

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).

Gene Name:

CYP11B1

Uniprot ID:

P15150

Molecular weight:

57847.0

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

Gene Name:

CYP17A1

Uniprot ID:

P05185

Molecular weight:

57244.0

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Gene Name:

CYP21

Uniprot ID:

P00191

Molecular weight:

56077.0

Reactions

General function:

Involved in prostaglandin-E synthase activity

Specific function:

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.

Gene Name:

PTGES3

Uniprot ID:

Q3ZBF7

Molecular weight:

18697.0

General function:

Involved in heme binding

Specific function:

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.

Gene Name:

PGRMC1

Uniprot ID:

Q17QC0

Molecular weight:

21622.0

General function:

Involved in steroid hormone receptor activity

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

O18972

Molecular weight:

14238.0

General function:

Involved in steroid hormone receptor activity

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q8MIL9

Molecular weight:

11223.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

PAQR6

Uniprot ID:

Q2KHW1

Molecular weight:

7035.0

General function:

Involved in sequence-specific DNA binding

Specific function:

Not Available

Gene Name:

PGR

Uniprot ID:

Q690N0

Molecular weight:

53591.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

PAQR9

Uniprot ID:

Q0II88

Molecular weight:

42786.0

General function:

Involved in prostaglandin F receptor activity

Specific function:

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).

Gene Name:

PTGFR

Uniprot ID:

P37289

Molecular weight:

41032.0

General function:

Involved in sequence-specific DNA binding

Specific function:

Not Available

Gene Name:

pr

Uniprot ID:

Q863K6

Molecular weight:

43590.0

General function:

Involved in zinc ion binding

Specific function:

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.

Gene Name:

TGFB1I1

Uniprot ID:

Q3MHZ4

Molecular weight:

49452.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

PAQR7

Uniprot ID:

Q2T9S9

Molecular weight:

39984.0