Showing metabocard for Inosinic acid (BMDB0000175)

General function:

Involved in 5'-nucleotidase activity

Specific function:

May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.

Gene Name:

NT5C2

Uniprot ID:

O46411

Molecular weight:

64841.0

Reactions

General function:

Not Available

Specific function:

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity).

Gene Name:

ENTPD8

Uniprot ID:

A0JND9

Molecular weight:

53240.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).

Gene Name:

GMPR2

Uniprot ID:

Q32L93

Molecular weight:

38033.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).

Gene Name:

HPRT1

Uniprot ID:

Q3SZ18

Molecular weight:

24498.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Gene Name:

ADSS1

Uniprot ID:

A5PJR4

Molecular weight:

50134.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Gene Name:

ITPA

Uniprot ID:

Q2KIC5

Molecular weight:

23061.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Gene Name:

ADSS2

Uniprot ID:

A7MBG0

Molecular weight:

50156.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.

Gene Name:

ATIC

Uniprot ID:

Q0VCK0

Molecular weight:

64483.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Gene Name:

GMPR

Uniprot ID:

Q08DA2

Molecular weight:

37504.0

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Gene Name:

IMPDH2

Uniprot ID:

Q3SWY3

Molecular weight:

55763.0

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Gene Name:

IMPDH1

Uniprot ID:

A0JNA3

Molecular weight:

55424.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

AMPD3

Uniprot ID:

E1BA23

Molecular weight:

52079.0

Reactions