Showing metabocard for Guanosine monophosphate (BMDB0001397)

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Gene Name:

APRT

Uniprot ID:

Q56JW4

Molecular weight:

19537.0

Reactions

General function:

Involved in 5'-nucleotidase activity

Specific function:

May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.

Gene Name:

NT5C2

Uniprot ID:

O46411

Molecular weight:

64841.0

Reactions

General function:

Involved in 3',5'-cyclic-GMP phosphodiesterase activity

Specific function:

As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.

Gene Name:

PDE6C

Uniprot ID:

P16586

Molecular weight:

98798.0

General function:

Involved in 3',5'-cyclic-GMP phosphodiesterase activity

Specific function:

This protein participates in processes of transmission and amplification of the visual signal.

Gene Name:

PDE6A

Uniprot ID:

P11541

Molecular weight:

99341.0

General function:

Involved in 3',5'-cyclic-GMP phosphodiesterase activity

Specific function:

This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.

Gene Name:

PDE6B

Uniprot ID:

P23439

Molecular weight:

98331.0

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).

Gene Name:

GMPR2

Uniprot ID:

Q32L93

Molecular weight:

38033.0

Reactions

General function:

Involved in 3',5'-cyclic-nucleotide phosphodiesterase a

Specific function:

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Gene Name:

PDE6H

Uniprot ID:

P22571

Molecular weight:

9102.0

General function:

Involved in 3',5'-cyclic-GMP phosphodiesterase activity

Specific function:

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity).

Gene Name:

PDE5A

Uniprot ID:

Q28156

Molecular weight:

98627.0

Reactions

General function:

Involved in 3',5'-cyclic-nucleotide phosphodiesterase a

Specific function:

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Gene Name:

PDE6G

Uniprot ID:

P04972

Molecular weight:

9669.0

General function:

Signal transduction mechanisms

Specific function:

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

Gene Name:

NPR2

Uniprot ID:

P46197

Molecular weight:

117146.0

General function:

Nucleotide transport and metabolism

Specific function:

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).

Gene Name:

HPRT1

Uniprot ID:

Q3SZ18

Molecular weight:

24498.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Gene Name:

ITPA

Uniprot ID:

Q2KIC5

Molecular weight:

23061.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:8243671, PubMed:29515371, PubMed:7911663). Involved in the cGMP metabolism in photoreceptors (PubMed:29515371, PubMed:8243671).

Gene Name:

GUK1

Uniprot ID:

P46195

Molecular weight:

21910.0

Reactions

General function:

Involved in GTP binding

Specific function:

Not Available

Gene Name:

GBP6

Uniprot ID:

Q0V7P3

Molecular weight:

23827.0

General function:

Involved in GTP binding

Specific function:

Not Available

Gene Name:

GBP1

Uniprot ID:

A5D955

Molecular weight:

25588.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

GMPS

Uniprot ID:

Q2T9U0

Molecular weight:

77865.0

Reactions

General function:

Not Available

Specific function:

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

Gene Name:

NUDT2

Uniprot ID:

Q29RJ1

Molecular weight:

16775.0

Reactions

General function:

Not Available

Specific function:

Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling (By similarity).

Gene Name:

ENTPD5

Uniprot ID:

E1BPW0

Molecular weight:

47888.0

Reactions