Showing metabocard for Tetrahydrobiopterin (BMDB0000027)

General function:

Inorganic ion transport and metabolism

Specific function:

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Gene Name:

NOS3

Uniprot ID:

P29473

Molecular weight:

133287.0

General function:

Inorganic ion transport and metabolism

Specific function:

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.

Gene Name:

NOS2

Uniprot ID:

Q27995

Molecular weight:

131208.0

General function:

Lipid transport and metabolism

Specific function:

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

Gene Name:

SPR

Uniprot ID:

Q17QK8

Molecular weight:

28939.0

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General function:

Amino acid transport and metabolism

Specific function:

Plays an important role in the physiology of adrenergic neurons.

Gene Name:

TH

Uniprot ID:

P17289

Molecular weight:

55123.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.

Gene Name:

PAH

Uniprot ID:

Q2KIH7

Molecular weight:

51727.0

General function:

Involved in arginine binding

Specific function:

Not Available

Gene Name:

iNOS

Uniprot ID:

Q6ZXD5

Molecular weight:

12093.0

General function:

Lipid transport and metabolism

Specific function:

The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.

Gene Name:

QDPR

Uniprot ID:

Q3T0Z7

Molecular weight:

25504.0

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General function:

Coenzyme transport and metabolism

Specific function:

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity).

Gene Name:

DHFR

Uniprot ID:

P00376

Molecular weight:

21604.0

Reactions