Showing metabocard for D-Mannose (BMDB0000169)

General function:

Involved in serine-type endopeptidase activity

Specific function:

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.

Gene Name:

PLAT

Uniprot ID:

Q28198

Molecular weight:

63701.0

General function:

Involved in ATP binding

Specific function:

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).

Gene Name:

HK1

Uniprot ID:

P27595

Molecular weight:

103064.0

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General function:

Carbohydrate transport and metabolism

Specific function:

Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense.

Gene Name:

CL43

Uniprot ID:

P42916

Molecular weight:

33616.0

General function:

Involved in glycoprotein binding

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q95M44

Molecular weight:

5436.0

General function:

Involved in mannose binding

Specific function:

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

Gene Name:

BSG

Uniprot ID:

Q865R3

Molecular weight:

22119.0

General function:

Involved in mannose binding

Specific function:

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Gene Name:

M6PR

Uniprot ID:

P11456

Molecular weight:

31201.0

General function:

Involved in binding

Specific function:

Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.

Gene Name:

COLEC11

Uniprot ID:

Q17QH6

Molecular weight:

28333.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

CL46

Uniprot ID:

Q8MHZ9

Molecular weight:

37445.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

lman1

Uniprot ID:

Q8MJ82

Molecular weight:

5976.0

General function:

Involved in calcium ion binding

Specific function:

Not Available

Gene Name:

MBL-A

Uniprot ID:

Q5I2B0

Molecular weight:

26308.0

General function:

Not Available

Specific function:

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity).

Gene Name:

FBXO6

Uniprot ID:

Q3SX24

Molecular weight:

30767.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q7M2U1

Molecular weight:

1267.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

PLIN3

Uniprot ID:

Q3SX32

Molecular weight:

47603.0

General function:

Involved in glycoprotein binding

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q862E4

Molecular weight:

15486.0

General function:

Carbohydrate transport and metabolism

Specific function:

Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N-acetylglucosamine, mannose, and fucose residues.

Gene Name:

CGN1

Uniprot ID:

P23805

Molecular weight:

37995.0

General function:

Cell cycle control, cell division, chromosome partitioning

Specific function:

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Gene Name:

bovine proacrosine

Uniprot ID:

P79343

Molecular weight:

41722.0

General function:

Involved in calcium ion binding

Specific function:

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).

Gene Name:

MBL

Uniprot ID:

O02659

Molecular weight:

26471.0

General function:

Involved in receptor activity

Specific function:

Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

Gene Name:

IGF2R

Uniprot ID:

P08169

Molecular weight:

274529.0

General function:

Not Available

Specific function:

Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity).

Gene Name:

NAGA

Uniprot ID:

Q58DH9

Molecular weight:

46533.0

Reactions