Showing metabocard for Ornithine (BMDB0000214)

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ARG1

Uniprot ID:

Q2KJ64

Molecular weight:

35009.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).

Gene Name:

GATM

Uniprot ID:

Q2HJ74

Molecular weight:

48357.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.

Gene Name:

ARG2

Uniprot ID:

Q58DL1

Molecular weight:

38616.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Gene Name:

ODC1

Uniprot ID:

P27117

Molecular weight:

51346.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ADC

Uniprot ID:

Q2TBX3

Molecular weight:

54147.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

OTC

Uniprot ID:

Q9N1U7

Molecular weight:

39842.0

Reactions

General function:

Involved in ornithine decarboxylase inhibitor activity

Specific function:

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.

Gene Name:

OAZ1

Uniprot ID:

Q56K12

Molecular weight:

25448.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

OAT

Uniprot ID:

Q3ZCF5

Molecular weight:

48075.0

Reactions

General function:

Involved in binding

Specific function:

Not Available

Gene Name:

SLC25A15

Uniprot ID:

Q2KHW4

Molecular weight:

32746.0