Showing metabocard for L-Methionine (BMDB0000696)

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

Gene Name:

MAT2A

Uniprot ID:

A7E3T7

Molecular weight:

43691.0

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

Gene Name:

LIAS

Uniprot ID:

Q5BIP7

Molecular weight:

42035.0

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

Gene Name:

MAT1A

Uniprot ID:

Q2KJC6

Molecular weight:

43761.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).

Gene Name:

MTR

Uniprot ID:

Q4JIJ3

Molecular weight:

140478.0

Reactions

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.

Gene Name:

MSRB1

Uniprot ID:

Q3MHL9

Molecular weight:

12833.0

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

Gene Name:

METAP1

Uniprot ID:

A6QLA4

Molecular weight:

43183.0

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

Gene Name:

METAP2

Uniprot ID:

Q3ZC89

Molecular weight:

52812.0

General function:

Amino acid transport and metabolism

Specific function:

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).

Gene Name:

BHMT

Uniprot ID:

Q5I597

Molecular weight:

44878.0

Reactions

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Gene Name:

MSRA

Uniprot ID:

P54149

Molecular weight:

25818.0

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Not Available

Gene Name:

MARS2

Uniprot ID:

A6H7E1

Molecular weight:

66648.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus.

Gene Name:

MARS1

Uniprot ID:

Q2T9L8

Molecular weight:

100634.0

Reactions

General function:

Involved in binding

Specific function:

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).

Gene Name:

SLC25A26

Uniprot ID:

A6QR09

Molecular weight:

29409.0

General function:

Not Available

Specific function:

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).

Gene Name:

MAT2B

Uniprot ID:

Q29RI9

Molecular weight:

37768.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

IL4I1

Uniprot ID:

F1N191

Molecular weight:

64479.0

Reactions

General function:

Not Available

Specific function:

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

Gene Name:

MSRB3

Uniprot ID:

E1BMD3

Molecular weight:

20644.0

Reactions