Showing metabocard for Ammonia (BMDB0000051)

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SDS

Uniprot ID:

Q0VCW4

Molecular weight:

34441.0

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity (By similarity).

Gene Name:

AOC3

Uniprot ID:

Q9TTK6

Molecular weight:

84500.0

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Gene Name:

HMBS

Uniprot ID:

Q2KIN5

Molecular weight:

39515.0

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

Gene Name:

PNPO

Uniprot ID:

Q5E9K3

Molecular weight:

30366.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).

Gene Name:

GMPR2

Uniprot ID:

Q32L93

Molecular weight:

38033.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

Gene Name:

ASRGL1

Uniprot ID:

Q32LE5

Molecular weight:

32050.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

DDO

Uniprot ID:

P31228

Molecular weight:

37660.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity).

Gene Name:

CTH

Uniprot ID:

Q58DW2

Molecular weight:

44406.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity).

Gene Name:

ADA

Uniprot ID:

P56658

Molecular weight:

40919.0

Reactions

General function:

Replication, recombination and repair

Specific function:

Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.

Gene Name:

GLUD1

Uniprot ID:

P00366

Molecular weight:

61512.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Gene Name:

MAOA

Uniprot ID:

P21398

Molecular weight:

59758.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

HAL

Uniprot ID:

A7YWP4

Molecular weight:

72291.0

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act as a monovalent cation transport.

Gene Name:

RHAG

Uniprot ID:

Q9GKN7

Molecular weight:

46719.0

General function:

Inorganic ion transport and metabolism

Specific function:

Functions as a specific ammonium transporter.

Gene Name:

RHBG

Uniprot ID:

Q95M77

Molecular weight:

49193.0

General function:

Inorganic ion transport and metabolism

Specific function:

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity).

Gene Name:

RHCG

Uniprot ID:

Q2T9S6

Molecular weight:

50834.0

General function:

Nucleotide transport and metabolism

Specific function:

Not Available

Gene Name:

DCTD

Uniprot ID:

A6QQC3

Molecular weight:

20039.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

IL4I1

Uniprot ID:

F1N191

Molecular weight:

64479.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

GLS2

Uniprot ID:

E1BHZ6

Molecular weight:

66700.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

CPS1

Uniprot ID:

F1ML89

Molecular weight:

164740.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

GMPS

Uniprot ID:

Q2T9U0

Molecular weight:

77865.0

Reactions

General function:

Not Available

Specific function:

Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Gene Name:

GNPDA1

Uniprot ID:

A4FV08

Molecular weight:

32580.0

Reactions

General function:

Not Available

Specific function:

Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells. It is also a negative regulator of primary T-cells.

Gene Name:

NIT1

Uniprot ID:

Q32LH4

Molecular weight:

36240.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

FTCD

Uniprot ID:

F1MNA6

Molecular weight:

60005.0

Reactions

General function:

Not Available

Specific function:

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

Gene Name:

GDA

Uniprot ID:

F1MLX9

Molecular weight:

51059.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

AMPD3

Uniprot ID:

E1BA23

Molecular weight:

52079.0

Reactions