Showing metabocard for Creatine (BMDB0000064)

General function:

Involved in ATP binding

Specific function:

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).

Gene Name:

CKMT2

Uniprot ID:

Q3ZBP1

Molecular weight:

47231.0

General function:

Involved in ATP binding

Specific function:

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).

Gene Name:

CKB

Uniprot ID:

Q5EA61

Molecular weight:

42719.0

Reactions

General function:

Involved in ATP binding

Specific function:

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).

Gene Name:

CKMT1

Uniprot ID:

Q9TTK8

Molecular weight:

46897.0

General function:

Involved in ATP binding

Specific function:

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).

Gene Name:

CKM

Uniprot ID:

Q9XSC6

Molecular weight:

42989.0

General function:

Involved in guanidinoacetate N-methyltransferase activity

Specific function:

Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.

Gene Name:

GAMT

Uniprot ID:

Q2TBQ3

Molecular weight:

26610.0

Reactions

General function:

Involved in transcription regulator activity

Specific function:

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Gene Name:

ID3

Uniprot ID:

Q5E981

Molecular weight:

12999.0

General function:

Involved in creatine:sodium symporter activity

Specific function:

Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).

Gene Name:

SLC6A8

Uniprot ID:

O18875

Molecular weight:

70676.0